Evidence map›Paper›PMID 40027668›Full record

ArticlebioRxiv : the preprint server for biology2025

The immunometabolic topography of tuberculosis granulomas governs cellular organization and bacterial control.

Erin F McCaffrey, Alea C Delmastro, Isobel Fitzhugh, Jolene S Ranek, Sarah Douglas, Joshua M Peters, Christine Camacho Fullaway, Marc Bosse, Candace C Liu, Craig Gillen and 23 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

33 authors.

Erin F McCaffreyDepartment of Pathology, Stanford University School of Medicine, Stanford, CA.ORCID 0000-0001-7241-1798
Alea C DelmastroDepartment of Pathology, Stanford University School of Medicine, Stanford, CA.ORCID 0000-0002-7959-3165
Isobel FitzhughThe Department of Biomedical Sciences and Technology, AdventHealth University, Orlando, FL.
Jolene S RanekDepartment of Pathology, Stanford University School of Medicine, Stanford, CA.
Sarah DouglasDepartment of Pathology, Stanford University School of Medicine, Stanford, CA.
Joshua M PetersDepartment of Biological Engineering, MIT, Cambridge, MA.
Christine Camacho FullawayDepartment of Pathology, Stanford University School of Medicine, Stanford, CA.
Marc BosseDepartment of Pathology, Stanford University School of Medicine, Stanford, CA.
Candace C LiuDepartment of Pathology, Stanford University School of Medicine, Stanford, CA.ORCID 0000-0002-2446-2264
Craig GillenThe Department of Biomedical Sciences and Technology, AdventHealth University, Orlando, FL.
Noah F GreenwaldDepartment of Pathology, Stanford University School of Medicine, Stanford, CA.
Sarah AnzickResearch Technologies Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT.
Craig MartensResearch Technologies Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT.
Seth WinfreeResearch Technologies Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT.
Yunhao BaiDepartment of Pathology, Stanford University School of Medicine, Stanford, CA.
Cameron SowersDepartment of Pathology, Stanford University School of Medicine, Stanford, CA.
Mako GoldstonDepartment of Pathology, Stanford University School of Medicine, Stanford, CA.
Alex KongDepartment of Pathology, Stanford University School of Medicine, Stanford, CA.
Potchara BoonratDepartment of Pathology, Stanford University School of Medicine, Stanford, CA.
Carolyn L BigbeeDepartment of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, PA.
Roopa VenugopalanCenter for Vaccine Research, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261.
Pauline MaielloDepartment of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, PA.
Edwin KleinDivision of Laboratory Animal Research, University of Pittsburgh, Pittsburgh, PA, USA.
Mark A RodgersDepartment of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, PA.
Charles A ScangaDepartment of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, PA.
Philana Ling LinCenter for Vaccine Research, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261.
Denise KirschnerDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI.
Sarah FortuneRagon Institute of Mass General, Harvard, and MIT, Cambridge, MA.
Bryan D BrysonDepartment of Biological Engineering, MIT, Cambridge, MA.ORCID 0000-0003-1716-6712
J Russell ButlerThe Department of Biomedical Sciences and Technology, AdventHealth University, Orlando, FL.
Joshua T MattilaCenter for Vaccine Research, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261.
JoAnne L FlynnDepartment of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, PA.
Michael AngeloDepartment of Pathology, Stanford University School of Medicine, Stanford, CA.ORCID 0000-0003-1531-5067

Funding

Dynamics of the cellular and molecular architecture of human pulmonary TB granulomasR01AI166313 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ROBERT L MODLIN · 2022 to 2026
$3.2M
Elucidating the mechanisms and consequences of MDSC-regulated immunity in TBR01AI164970 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Bryan David Bryson, Joshua T. Mattila · 2022 to 2026
$2.7M
USING DEEP MUTATIONAL SCANNING TO CHARACTERIZE TUMOR-IMMUNE INTERACTIONSK00CA264307 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NOAH GREENWALD · 2025 to 2026
$192k
Comprehensive profiling of the tumor microenvironment to predict patient response to immunotherapyF99CA264307 · NCI · STANFORD UNIVERSITY · PI GREENWALD, NOAH · 2021 to 2022
$79k
Predicting response to anti-PD-1 therapy in triple negative breast cancer by comprehensive profiling of the tumor microenvironmentF31CA246880 · NCI · STANFORD UNIVERSITY · PI GREENWALD, NOAH · 2020 to 2021
$53k
NCI NIH HHS F31 CA246880NCI NIH HHS F99 CA264307NCI NIH HHS K00 CA264307NIAID NIH HHS R01 AI164970NIAID NIH HHS R01 AI166313Wellcome Trust
6 · The paper itself

Abstract

Despite being heavily infiltrated by immune cells, tuberculosis (TB) granulomas often subvert the host response to

Identifiers

PMID40027668
PMCPMC11870603

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.