ArticlebioRxiv : the preprint server for biology2025
Synergistic RAS-MAPK and AKT Activation in MYC-Driven Tumors via Adjacent PVT1 Rearrangements.
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Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
45 authors.
Ashutosh TiwariCancer Genome and Epigenetics Program, NCI Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Utkarsha PaithaneCancer Genome and Epigenetics Program, NCI Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Jordan FriedleinCancer Genome and Epigenetics Program, NCI Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Kojiro TashiroCancer Genome and Epigenetics Program, NCI Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Olivier SaulnierDevelopmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.
Karina BarbosaCancer Genome and Epigenetics Program, NCI Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.ORCID 0000-0002-6233-3332
Quang TrinhAdaptive Oncology, Ontario Institute for Cancer Research, Toronto, ON, Canada.
Bryan HallCancer Genome and Epigenetics Program, NCI Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Shrawantee SahaCancer Genome and Epigenetics Program, NCI Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Aditi SoniCancer Genome and Epigenetics Program, NCI Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Takuma NakashimaDivision of Brain Tumor Translational Research, National Cancer Center Research Institute, Chuo-ku, Tokyo, 104-0045, Japan.
Andrey BobkovCancer Genome and Epigenetics Program, NCI Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Lynn Miya FujimotoCancer Genome and Epigenetics Program, NCI Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Rabi MuradCancer Genome and Epigenetics Program, NCI Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Svetlana MauryaCancer Genome and Epigenetics Program, NCI Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Mayank SaraswatCancer Genome and Epigenetics Program, NCI Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Shahab SarmashghiDepartment of Medical Oncology and Center for Neuro-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Joshua T LangeDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Sihan WuDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0001-8329-7492
Meher Beigi MasihiCancer Genome and Epigenetics Program, NCI Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Srija GhoshCancer Genome and Epigenetics Program, NCI Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Gazal HemmatiCancer Genome and Epigenetics Program, NCI Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Owen ChapmanBioinformatics and Systems Biology Graduate Program, University of California San Diego, San Diego, CA, USA.ORCID 0000-0001-7923-9273
Liam HendrikseDevelopmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.ORCID 0000-0002-0253-8512
Brian JamesCancer Genome and Epigenetics Program, NCI Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Jens LuebeckDepartment of Computer Science, University of California San Diego, La Jolla, CA.
Tanja EisemannCancer Genome and Epigenetics Program, NCI Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Theophilos TzaridisCancer Genome and Epigenetics Program, NCI Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Deepak RohilaCancer Genome and Epigenetics Program, NCI Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Robyn LearyMasonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.
Jyotika VarshneyMasonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.
Badrinath KonetyMasonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.
Scott M DehmMasonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.
Yasuhiko KawakamiDepartment of Pediatrics, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0002-0043-9705
Rameen BeroukhimDepartment of Medical Oncology and Center for Neuro-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
David A LargaespadaDepartment of Pediatrics, University of Minnesota, Minneapolis, MN, USA.
Lincoln SteinAdaptive Oncology, Ontario Institute for Cancer Research, Toronto, ON, Canada.
Lukas ChavezCancer Genome and Epigenetics Program, NCI Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Hiromichi SuzukiDivision of Brain Tumor Translational Research, National Cancer Center Research Institute, Chuo-ku, Tokyo, 104-0045, Japan.
William A WeissDepartments of Neurology, Pediatrics, and Neurological Surgery, Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA.
Jianhua ZhaoCancer Genome and Epigenetics Program, NCI Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.ORCID 0000-0002-4997-766X
Aniruddha DeshpandeCancer Genome and Epigenetics Program, NCI Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Robert J Wechsler-ReyaCancer Genome and Epigenetics Program, NCI Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Michael D TaylorDevelopmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.
Anindya BagchiCancer Genome and Epigenetics Program, NCI Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Funding
Identifying and Targeting the Drivers of Pediatric Brain TumorsR35NS122339 · NINDS · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI Robert J. Wechsler-Reya · 2021 to 2026
$3.6MRole of the Long Non-coding RNA PVT1 in CancerR01CA200643 · NCI · UNIVERSITY OF MINNESOTA · PI BAGCHI, ANINDYA · 2016 to 2020
$2.1MNCI NIH HHS R01 CA200643NINDS NIH HHS R35 NS122339
Abstract
MYC-driven (MYC+) cancers are aggressive and often fatal. MYC dysregulation is a key event in these cancers, but overexpression of MYC alone is not always enough to cause cancer.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.