Evidence map›Paper›PMID 40027560›Full record

ArticleWorld journal of hepatology2025

Pathological features of non-alcoholic steatohepatitis in a pediatric patient with heterozygous familial hypobetalipoproteinemia: A case report.

Kiwako Miyamoto, Sonoko Kondo, Takeo Kondo, Ryou Ishikawa, Ryosuke Tani, Tomoko Inoue, Keiji Matsunaga, Tetsuo Minamino, Takashi Kusaka

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of hepatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

9 authors.

Kiwako MiyamotoDepartment of Pediatrics, Faculty of Medicine, Kagawa University, Miki 761-0793, Kagawa, Japan.
Sonoko KondoDepartment of Pediatrics, Faculty of Medicine, Kagawa University, Miki 761-0793, Kagawa, Japan. ijichi.sonoko@kagawa-u.ac.jp.
Takeo KondoDepartment of Pediatrics, Faculty of Medicine, Kagawa University, Miki 761-0793, Kagawa, Japan.
Ryou IshikawaDepartment of Diagnostic Pathology, Faculty of Medicine, Kagawa University, Miki 761-0793, Kagawa, Japan.
Ryosuke TaniDepartment of Cardiorenal and Cerebrovascular Medicine, Faculty of Medicine, Kagawa University, Miki 761-0793, Kagawa, Japan.
Tomoko InoueDepartment of Cardiorenal and Cerebrovascular Medicine, Faculty of Medicine, Kagawa University, Miki 761-0793, Kagawa, Japan.
Keiji MatsunagaDepartment of Cardiorenal and Cerebrovascular Medicine, Faculty of Medicine, Kagawa University, Miki 761-0793, Kagawa, Japan.
Tetsuo MinaminoDepartment of Cardiorenal and Cerebrovascular Medicine, Faculty of Medicine, Kagawa University, Miki 761-0793, Kagawa, Japan.
Takashi KusakaDepartment of Pediatrics, Faculty of Medicine, Kagawa University, Miki 761-0793, Kagawa, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHeterozygous familial hypobetalipoproteinemia (FHBL) is a semi-autosomal disorder that is caused mainly by an CASE SUMMARY: A 12-year-old boy was referred to our hospital after prolonged elevation of liver enzymes was observed during health checkups in Kagawa Prefecture. Abdominal ultrasound showed a bright liver, and laboratory investigations revealed low low-density lipoprotein cholesterol and apolipoprotein B protein levels. His family history included fatty liver and hypolipidemia in his father, which led to a clinical diagnosis of FHBL. A liver biopsy was performed on suspicion of liver fibrosis based on biomarkers. The liver tissue showed fatty steatosis, inflammation, hepatocyte ballooning, and fibrosis, indicating NASH. Genetic testing detected the

conclusionIt is important to assess family history and liver dysfunction severity in non-obese patients with hypolipidemia and fatty liver.

Indexed as

APOB variantCase reportFamilial hypobetalipoproteinemiaHypolipidemiaNonalcoholic steatohepatitisVitamin E

Identifiers

PMID40027560
PMCPMC11866159

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