Evidence map›Paper›PMID 40027545›Full record

ArticleAPL bioengineering2025

Adenine base editing rescues pathogenic phenotypes in tissue engineered vascular model of Hutchinson-Gilford progeria syndrome.

Nadia O Abutaleb, Xin D Gao, Akhil Bedapudi, Leandro Choi, Kevin L Shores, Crystal Kennedy, Jordyn E Duby, Kan Cao, David R Liu, George A Truskey

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in APL bioengineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. CRISPR-mediated targeting of theMolecular therapy. Advances · 2026
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nadia O AbutalebDepartment of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA.ORCID https://orcid.org/0000-0002-0995-5730
Xin D GaoORCID https://orcid.org/0000-0003-2917-2060
Akhil BedapudiDepartment of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA.ORCID https://orcid.org/0000-0001-8008-5822
Leandro ChoiDepartment of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA.ORCID https://orcid.org/0000-0001-8965-9896
Kevin L ShoresDepartment of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA.ORCID https://orcid.org/0000-0002-6205-8318
Crystal KennedyUniversity Program in Genetics and Genomics, Duke University, Durham, North Carolina 27708, USA.ORCID https://orcid.org/0000-0003-3405-3381
Jordyn E DubyORCID https://orcid.org/0009-0001-2638-2946
Kan CaoDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland 20742, USA.ORCID https://orcid.org/0000-0002-5806-2939
David R LiuORCID https://orcid.org/0000-0002-9943-7557
George A TruskeyDepartment of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA.ORCID https://orcid.org/0000-0002-6885-4489

Funding

In Vitro Human Tissue-Engineered Blood Vessel Disease Model of ProgeriaR01HL138252 · NHLBI · DUKE UNIVERSITY · PI TRUSKEY, GEORGE A · 2017 to 2025
$4.7M
Vascular, Cardiac, and Lung Alveolar Human Microphysiological Systems for SARS-CoV-2 Drug ScreeningUH3TR002142 · NCATS · DUKE UNIVERSITY · PI TRUSKEY, GEORGE A · 2019 to 2021
$4.0M
Investigating the Effects of Hutchinson-Gilford Progeria Syndrome Mutation Correction in Tissue-Engineered Blood VesselsF31HL172589 · NHLBI · DUKE UNIVERSITY · PI SHORES, KEVIN · 2024 to 2025
$85k
NCATS NIH HHS UH3 TR002142NHLBI NIH HHS F31 HL172589NHLBI NIH HHS R01 HL138252
6 · The paper itself

Abstract

The rare, accelerated aging disease Hutchinson-Gilford Progeria Syndrome (HGPS) is commonly caused by a

Identifiers

PMID40027545
PMCPMC11871533

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.