Evidence map›Paper›PMID 40027514›Full record

ArticleFrontiers in cardiovascular medicine2025

Inducing hypertension in

Callie S Kwartler, Shanzhi Wang, Zhen Zhou, Pujun Guan, Yang Yu, Xue-Yan Duan, Theodore Zhang, Jiyuan Chen, Elaine C Davis, Dianna M Milewicz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Callie S Kwartler *Division of Medical Genetics, Department of Internal Medicine, The University of Texas Health Science Center at Houston, Houston, TX, United States.
Shanzhi Wang *Division of Medical Genetics, Department of Internal Medicine, The University of Texas Health Science Center at Houston, Houston, TX, United States.
Zhen Zhou *Division of Medical Genetics, Department of Internal Medicine, The University of Texas Health Science Center at Houston, Houston, TX, United States.
Pujun GuanDivision of Medical Genetics, Department of Internal Medicine, The University of Texas Health Science Center at Houston, Houston, TX, United States.
Yang YuDivision of Medical Genetics, Department of Internal Medicine, The University of Texas Health Science Center at Houston, Houston, TX, United States.
Xue-Yan DuanDivision of Medical Genetics, Department of Internal Medicine, The University of Texas Health Science Center at Houston, Houston, TX, United States.
Theodore ZhangDivision of Medical Genetics, Department of Internal Medicine, The University of Texas Health Science Center at Houston, Houston, TX, United States.
Jiyuan ChenDivision of Medical Genetics, Department of Internal Medicine, The University of Texas Health Science Center at Houston, Houston, TX, United States.
Elaine C DavisDepartment of Anatomy and Cell Biology, McGill University, Montreal, QC, Canada.
Dianna M MilewiczDivision of Medical Genetics, Department of Internal Medicine, The University of Texas Health Science Center at Houston, Houston, TX, United States.

Funding

Genetic Predisposition To Thoracic Aortic Aneurysms/DissectionsR01HL109942 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MILEWICZ, DIANNA M · 2012 to 2023
$7.5M
Novel genetic Insight into the molecular pathogenesis of atherosclerosisR01HL146583 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MILEWICZ, DIANNA M · 2019 to 2022
$2.6M
NHLBI NIH HHS R01 HL109942NHLBI NIH HHS R01 HL146583
6 · The paper itself

Abstract

Objective: We sought to determine if hypertension in combination with a "variant of uncertain significance" that disrupts protein function, Approach and results: Administration of L-NAME via drinking water and a high salt diet increased blood pressure in WT and Conclusion: Gene-environment interactions trigger aortic dissections in

Indexed as

aortic dissectionelastin-contractile unitfocal adhesionmyosin heavy chainsmooth muscle cell (SMC)thoracic aortic dissectionvascular disease

Identifiers

PMID40027514
PMCPMC11868086

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.