Evidence map›Paper›PMID 40027477›Full record

ReviewiMeta2025

Gut-X axis.

Xu Lin, Zuxiang Yu, Yang Liu, Changzhou Li, Hui Hu, Jia-Chun Hu, Mian Liu, Qin Yang, Peng Gu, Jiaxin Li and 15 more

Erratum issuedAbstract readReview
In one paragraph

Review in iMeta, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 80 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Indole-3-carboxaldehyde fromGut microbes · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Gut microbiota in health and disease.Molecular biomedicine · 2026
    Review
  15. Article
  16. Article
  17. [Gut microbiota and allergic diseases].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026
    Review
  18. Article
  19. Regulatory T cells in cancer and inflammation.Signal transduction and targeted therapy · 2026
    Review
  20. Review

20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

25 authors.

Xu LinDepartment of Endocrinology and Metabolism Shunde Hospital of Southern Medical University (The First People's Hospital of Shunde) Foshan City 528308 China.
Zuxiang YuState Key Laboratory of Vascular Homeostasis and Remodeling, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing Key Laboratory of Cardiovascular Receptors Research, Health Science Center, The Institute of Cardiovascular Sciences and Institute of Systems Biomedicine Peking University Beijing 100191 China.
Yang LiuState Key Laboratory of Reproductive Medicine and Offsprings Health, Center for Global Health Nanjing Medical University Nanjing 211166 China.
Changzhou LiDepartment of Plastic and Aesthetic Surgery, Nanfang Hospital Southern Medical University Guangzhou 510515 China.
Hui HuDepartment of Laboratory Medicine, Shanghai East Hospital Tongji University School of Medicine Shanghai 200123 China.
Jia-Chun HuState Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia Medica, Chinese Academy of Medical Sciences/Peking Union Medical College Beijing 100050 China.
Mian LiuDepartment of Obstetrics and Gynecology, Nanfang Hospital Southern Medical University Guangzhou 510515 China.
Qin YangDepartment of Pathophysiology, Guangdong Provincial Key Laboratory of Proteomics, School of Basic Medical Sciences Southern Medical University Guangzhou 510515 China.
Peng GuDepartment of Pathophysiology, Guangdong Provincial Key Laboratory of Proteomics, School of Basic Medical Sciences Southern Medical University Guangzhou 510515 China.
Jiaxin LiDepartment of Pathophysiology, Guangdong Provincial Key Laboratory of Proteomics, School of Basic Medical Sciences Southern Medical University Guangzhou 510515 China.
Kutty Selva NandakumarDepartment of Medical Biochemistry and Biophysics Karolinska Institute Stockholm 17177 Sweden.ORCID 0000-0001-7790-8197
Gaofei HuState Key Laboratory of Vascular Homeostasis and Remodeling, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing Key Laboratory of Cardiovascular Receptors Research, Health Science Center, The Institute of Cardiovascular Sciences and Institute of Systems Biomedicine Peking University Beijing 100191 China.
Qi ZhangState Key Laboratory of Vascular Homeostasis and Remodeling, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing Key Laboratory of Cardiovascular Receptors Research, Health Science Center, The Institute of Cardiovascular Sciences and Institute of Systems Biomedicine Peking University Beijing 100191 China.
Xinyu ChenState Key Laboratory of Reproductive Medicine and Offsprings Health, Center for Global Health Nanjing Medical University Nanjing 211166 China.
Huihui MaState Key Laboratory of Reproductive Medicine and Offsprings Health, Center for Global Health Nanjing Medical University Nanjing 211166 China.
Wenye HuangState Key Laboratory of Reproductive Medicine and Offsprings Health, Center for Global Health Nanjing Medical University Nanjing 211166 China.ORCID 0009-0002-0265-6145
Gaofeng WangDepartment of Plastic and Aesthetic Surgery, Nanfang Hospital Southern Medical University Guangzhou 510515 China.
Yan WangState Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia Medica, Chinese Academy of Medical Sciences/Peking Union Medical College Beijing 100050 China.
Liping HuangDepartment of Obstetrics and Gynecology, Nanfang Hospital Southern Medical University Guangzhou 510515 China.
Wenjuan WuDepartment of Laboratory Medicine, Shanghai East Hospital Tongji University School of Medicine Shanghai 200123 China.
Ning-Ning LiuState Key Laboratory of Systems Medicine for Cancer, Center for Single-Cell Omics, School of Public Health Shanghai Jiao Tong University School of Medicine Shanghai 200025 China.
Chenhong ZhangState Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology Shanghai Jiao Tong University Shanghai 200240 China.ORCID 0000-0002-4462-892X
Xingyin LiuState Key Laboratory of Reproductive Medicine and Offsprings Health, Center for Global Health Nanjing Medical University Nanjing 211166 China.ORCID 0000-0001-8770-3494
Leming ZhengState Key Laboratory of Vascular Homeostasis and Remodeling, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing Key Laboratory of Cardiovascular Receptors Research, Health Science Center, The Institute of Cardiovascular Sciences and Institute of Systems Biomedicine Peking University Beijing 100191 China.
Peng ChenDepartment of Pathophysiology, Guangdong Provincial Key Laboratory of Proteomics, School of Basic Medical Sciences Southern Medical University Guangzhou 510515 China.ORCID 0000-0003-0473-205X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent advances in understanding the modulatory functions of gut and gut microbiota on human diseases facilitated our focused attention on the contribution of the gut to the pathophysiological alterations of many extraintestinal organs, including the liver, heart, brain, lungs, kidneys, bone, skin, reproductive, and endocrine systems. In this review, we applied the "gut-X axis" concept to describe the linkages between the gut and other organs and discussed the latest findings related to the "gut-X axis," including the underlying modulatory mechanisms and potential clinical intervention strategies.

Indexed as

bonebraingutheartkidneyliverlung

Identifiers

PMID40027477
PMCPMC11865426

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.