ArticleJournal of Brown hospital medicine2025
Lentiform Fork Sign Secondary To Metformin-Induced Encephalopathy.
Article in Journal of Brown hospital medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Metformin-induced encephalopathy in a peritoneal dialysis patient: the critical role of hemodialysis in reversing lentiform fork sign: a case report.BMC neurology · 2026Article
- A hemodialysis patient with recurrent Wernicke encephalopathy showed reversible lentiform fork sign: A case report.Medicine · 2026Article
- Article
- Metformin-Associated Encephalopathy as a Rare but Serious Adverse Effect: A Case Report.Cureus · 2026Article
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Authors and funding
1 author.
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No grant is acknowledged in the PubMed record.
Abstract
The Lentiform Fork sign is an imaging finding on brain MRI described by bilateral, symmetric hyperintensities in the basal ganglia. It is described in the setting of metabolic acidosis of many etiologies and is a sign of vasogenic edema. Both imaging findings and symptoms are often reversible with correction of the acidosis and removal of any identifiable triggers. We report a case of confusion and ataxic gait in a patient with end stage renal disease and ongoing metformin use. The mechanism of metformin-induced encephalopathy remains unclear, but could be due to vulnerability of mitochondria to metformin within the lentiform nuclei.
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