ArticleJournal of cardiovascular and thoracic research2024
The protective effect of Edaravone against acute renocardiac syndrome in a kidney ischemia-reperfusion model.
Article in Journal of cardiovascular and thoracic research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Acute kidney injury (AKI) is a common clinical occurrence causing high mortality and morbidity. In acute renocardiac syndrome, AKI leads to acute cardiac injury or/and dysfunction. This study aimed to investigate the antioxidative effects of Edaravone on cardiac tissues following the induction of renal ischemia-reperfusion injury (IRI) in rats. Methods: Twenty-four male Wistar rats were randomly divided into four groups: IR+Edaravone, Edaravone, IR, and Sham groups (six rats per group). Non-traumatic clamps were used to stop the artery and vein blood flow of the left kidney in rats of the IR groups for 45 minutes. Thirty minutes before ischemia induction, Edaravone (3 mg/kg) was injected intraperitoneally in the IR+Edaravone group. Cardiac samples were subjected to biochemical analyses. Results: The Results showed a significant increase in the enzymatic activity of glutathione peroxidase ( Conclusion: The results can reveal important insights into the protective effects of Edaravone against acute renocardiac syndrome.
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