ArticleFood science & nutrition2025
Assessing Traditional Chinese Medicines for Anti-Dengue Using a National Health Insurance Research Database and Bioassays.
Article in Food science & nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Integrating the Wei-Qi-Ying-Blood Theory with Modern Pathophysiology: A Multitarget Translational Framework for Dengue Management.International journal of general medicine · 2026Review
- Qingqi Guxue Decoction induces S cell cycle arrest to inhibit replication of severe fever with thrombocytopenia syndrome virus.Virologica Sinica · 2025Article
- Early diagnostic value of dengue virus NS1 antigen and nucleic acid testing.American journal of translational research · 2025Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dengue fever is a widespread viral infectious disease transmitted by mosquitoes. Despite the potentially fatal consequences for some individuals, no antiviral drugs have been approved for the treatment of this disease. Taiwan's National Health Insurance Database (NHID) holds extensive medical records for almost every resident, encompassing conventional and traditional Chinese medicine (TCM) treatments. This study aims to uncover potential TCM formulas with antiviral properties against dengue fever by analyzing NHID data. Initially, the NHID was screened to identify candidate TCM formulas. Subsequently, immunofluorescence assays were conducted to evaluate the anti-dengue virus (DENV) effects of these TCM compounds. Selected TCM formulas underwent testing for cytotoxicity and anti-DENV activity. The study identified 62 promising TCM formulas, focusing on those most frequently prescribed and their potential efficacy. Among these, 23 TCM formulas showed promise in preventing severe illness, with 20 subjected to further analysis for cytotoxicity and anti-DENV effects. Notably, Gastrodiae Rhizoma and Pinellia Rhizoma exhibited significant anti-DENV activity at different multiplicities of infection (MOIs). This research introduces a novel methodology for identifying potential antiviral compounds against dengue fever, leveraging NHID data alongside immunofluorescence assays.
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