Evidence map›Paper›PMID 40027274›Full record

ArticleAdvanced functional materials2024

Exosomal Bupivacaine: Integrating Nerve Barrier Penetration Capability and Sustained Drug Release for Enhanced Potency in Peripheral Nerve Block and Reduced Toxicity.

Yuhao Cai, Qi Li, Ursula Wesselmann, Chao Zhao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced functional materials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yuhao CaiDepartment of Chemical and Biological Engineering, University of Alabama, Tuscaloosa, AL, 35487, USA.
Qi LiDepartment of Chemical and Biological Engineering, University of Alabama, Tuscaloosa, AL, 35487, USA.
Ursula WesselmannDepartments of Anesthesiology and Perioperative Medicine/Division of Pain Medicine, Neurology and Psychology, and Consortium for Neuroengineering and Brain-Computer Interfaces, The University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Chao ZhaoDepartment of Chemical and Biological Engineering, University of Alabama, Tuscaloosa, AL, 35487, USA.

Funding

Nanoparticles with Two-Stage Delivery of Tetrodotoxin for Prolonged Duration Local AnesthesiaR61NS123196 · NINDS · UNIVERSITY OF ALABAMA IN TUSCALOOSA · PI ZHAO, CHAO · 2022 to 2023
$653k
NINDS NIH HHS R61 NS123196
6 · The paper itself

Abstract

Peripherally injected local anesthetics exhibit limited ability to penetrate peripheral nerve barriers (PNBs), which limits their effectiveness in peripheral nerve block and increases the risk of adverse effects. In this work, we demonstrated that exosomes derived from Human Embryo Kidney (HEK) 293 cells can effectively traverse the perineurium, which is the rate-limiting barrier within PNBs that local anesthetics need to cross before acting on axons. Based on this finding, we use these exosomes as a carrier for bupivacaine (BUP), a local anesthetic commonly used in clinical settings. The

Indexed as

Exosomeslocal anesthesianerve barrier penetrationnerve blockadepain management

Identifiers

PMID40027274
PMCPMC11870390

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.