Evidence map›Paper›PMID 40027230›Full record

ReviewThe journal of liquid biopsy2025

Liquid biopsy in gastric cancer: A snapshot of the current state of the art.

Jessica Gasparello, Carlotta Ceccon, Valentina Angerilli, Tatiane Comunello, Marianna Sabbadin, Felipe D'Almeida Costa, Antonio Antico, Claudio Luchini, Paola Parente, Francesca Bergamo and 2 more

Abstract readReview
In one paragraph

Review in The journal of liquid biopsy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jessica GasparelloDepartment of Medicine - DIMED, University of Padova, Padova, Italy.
Carlotta CecconDepartment of Medicine - DIMED, University of Padova, Padova, Italy.
Valentina AngerilliDepartment of Medicine - DIMED, University of Padova, Padova, Italy.
Tatiane ComunelloDepartment of Pathology, A.C. Camargo Cancer Center, Sao Paulo, Brazil.
Marianna SabbadinDepartment of Medicine - DIMED, University of Padova, Padova, Italy.
Felipe D'Almeida CostaDepartment of Pathology, A.C. Camargo Cancer Center, Sao Paulo, Brazil.
Antonio AnticoDepartment of Clinical Pathology, Azienda ULSS2 Marca Trevigiana, Treviso, Italy.
Claudio LuchiniDepartment of Diagnostics and Public Health, Section of Pathology, University and Hospital Trust of Verona, Verona, Italy.
Paola ParenteUnit of Pathology, Fondazione IRCCS Ospedale Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, Italy.
Francesca BergamoVeneto Institute of Oncology IOV-IRCCS, Padua, Italy.
Sara LonardiVeneto Institute of Oncology IOV-IRCCS, Padua, Italy.
Matteo FassanDepartment of Medicine - DIMED, University of Padova, Padova, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circulating tumor DNA (ctDNA) is nowadays considered a robust source to search for druggable tumoral genetic alterations, and in some specific settings liquid biopsy (LB) is already part of the diagnostics scenario and it has successfully implemented in the everyday practice. Three strengths make LB an extraordinary tool: i) to represent the complex molecular mosaicism that characterizes spatially heterogeneous malignancies; ii) to monitor in real-time the tumoral molecular landscape (i.e. to depict the longitudinal/temporal tumor evolution); iii) to ensure molecular profiling even in those cases in which tissue sampling is not feasible or not adequate. This review provides a snapshot of the current state of the art concerning ctDNA assay utility in gastric cancer (GC), testing its robustness as marker and seeking to understand the reasons for the delay in its application in clinical practice.

Indexed as

Circulating markersCNAsctDNAGastric cancerLiquid biopsy

Identifiers

PMID40027230
PMCPMC11863821

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.