Evidence map›Paper›PMID 40027162›Full record

ArticleFrontiers in neurology2025

Clinical implications of real-time optic nerve sheath diameter assessment via critical care ultrasound in intracranial hypertension.

Nan Zhang, Meng Liang, Tenghao Shao, Ning Li, Kuo Wang, Shuo Sun, Tao Sun

Registry-linked trialAbstract read
In one paragraph

Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07786324 (Comparison of 3% Hypertonic Saline Versus 20% Mannitol in Reduction of Increased Intracranial Pressure in Patients With Traumatic Brain Injury Using Optic Nerve Sheath Diameter Measurements''), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07786324 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Comparison of 3% Hypertonic Saline Versus 20% Mannitol in Reduction of Increased Intracranial Pressure in Patients With Traumatic Brain Injury Using Optic Nerve Sheath Diameter Measurements''

TypeinterventionalSponsorAssiut UniversityRan2026 to 2029Enrolled100ConditionsTBI (Traumatic Brain Injury), ICP (Intracranial Pressure) Increase, Optic Nerve Sheath Diameter MeasurementArmsMannitol (20%), Hypertonic Saline ( 3% Sodium Chloride Saline)
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Observational
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nan Zhang *Department of Critical Care Medicine, Affiliated Hospital of Hebei University, Baoding, Hebei, China.
Meng Liang *Department of Hepatobiliary Surgery, Affiliated Hospital of Hebei University, Baoding, Hebei, China.
Tenghao ShaoDepartment of Critical Care Medicine, Affiliated Hospital of Hebei University, Baoding, Hebei, China.
Ning LiDepartment of Critical Care Medicine, Affiliated Hospital of Hebei University, Baoding, Hebei, China.
Kuo WangDepartment of Critical Care Medicine, Affiliated Hospital of Hebei University, Baoding, Hebei, China.
Shuo SunDepartment of Neurosurgery, Affiliated Hospital of Hebei University, Baoding, Hebei, China.
Tao SunDepartment of Critical Care Medicine, Affiliated Hospital of Hebei University, Baoding, Hebei, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: This study aims to assess the clinical value of dynamic monitoring of optic nerve sheath diameter using critical care ultrasound in the management of patients with intracranial hypertension. Methods: A total of 130 patients with craniocerebral injuries, treated at the Department of Critical Care Medicine of the Affiliated Hospital of Hebei University from January 2021 to November 2022, were selected and randomly assigned to either the control group (65 patients) or the observation group (65 patients). Patients in both groups were monitored based on clinical symptoms, cranial CT findings, and optic nerve sheath diameter (ONSD). The control group received standard osmotic therapy to manage intracranial pressure (ICP), while the observation group was guided accordingly. Comparative analyses were conducted on Acute Physiology and Chronic Health Evaluation II (APACHE II) scores, Glasgow Coma Scale (GCS) scores, duration of ICU stay, and mechanical ventilation time between the two groups. Results: On the 28th day, the APACHE II scores of patients with craniocerebral injuries in both groups were significantly lower compared to admission scores, while GCS scores were higher ( Conclusion: Dynamic monitoring of ONSD using bedside critical care ultrasound has proven effective in guiding osmotic therapy for patients with intracranial hypertension. This approach significantly reduces ICP, offers a reliable basis to opt for subsequent treatments, and effectively lowers the rate of disability while improving patient prognosis.

Indexed as

critical care ultrasoundintracranial hypertensionoptic nerve sheath widthreal-time monitoringultrasound measurement

Identifiers

PMID40027162
PMCPMC11869381

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.