ArticleFrontiers in oncology2025
Survival prognostic nomogram for young metastatic non-small cell lung cancer: a study of the US SEER database and a Chinese cohort.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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6 authors.
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Abstract
Objective: Young patients diagnosed with non-small cell lung cancer (NSCLC) present unique clinical, pathological, and genetic features, resulting in a highly heterogeneous patient population. The current TNM staging system is insufficient for accurately predicting their prognosis. This study aims to develop a nomogram model for survival prediction in young patients with metastatic NSCLC at initial diagnosis and further verify the effectiveness of the model. Methods: This study enrolled 961 young patients diagnosed with metastatic NSCLC in the Surveillance, Epidemiology, and End Results (SEER) database between 2010 and 2017. The patients were allocated into a training cohort ( Results: The multifactorial Cox regression model identified eight independent risk factors influencing overall survival (OS): race, marital status, histological type, T stage, N stage, liver metastasis, chemotherapy, and radiotherapy (all Conclusions: A nomogram model has been developed and validated to accurately predict the OS of young patients with metastatic NSCLC at initial diagnosis, demonstrating superior performance compared to the traditional TNM staging system. This model offers valuable guidance for precise predictions and making rational treatment decisions in clinical practice.
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