Evidence map›Paper›PMID 40027047›Full record

ArticleCureus2025

Profiling the Effect of Micronutrient Levels on Vital Cardiovascular Markers.

Hari K Krishnamurthy, Swarnkumar Reddy, Vasanth Jayaraman, Karthik Krishna, Qi Song, Tianhao Wang, Kang Bei, John J Rajasekaran

Abstract read
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. The Yin and Yang of copper in cardiovascular health and disease.Molecular and cellular biochemistry · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hari K KrishnamurthyResearch and Development, Vibrant Sciences LLC, San Carlos, USA.
Swarnkumar ReddyClinical Laboratory, Vibrant America LLC, Santa Clara, USA.
Vasanth JayaramanResearch and Development, Vibrant Sciences LLC, San Carlos, USA.
Karthik KrishnaResearch and Development, Vibrant Sciences LLC, San Carlos, USA.
Qi SongClinical Laboratory, Vibrant America LLC, San Carlos, USA.
Tianhao WangResearch and Development, Vibrant Sciences LLC, San Carlos, USA.
Kang BeiResearch and Development, Vibrant Sciences LLC, San Carlos, USA.
John J RajasekaranResearch and Development, Vibrant Sciences LLC, San Carlos, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction Cardiovascular diseases (CVDs) remain the leading cause of mortality globally. The role of micronutrients in maintaining cardiovascular health has gained increasing attention, as deficiencies or imbalances in vitamins, minerals, and amino acids may influence the risk and progression of CVDs. This study aimed to evaluate the relationship between serum micronutrient levels and critical lipid and lipoprotein markers indicative of cardiovascular health. Materials and methods A retrospective analysis was conducted on 358 individuals who underwent testing for the Cardio Health and Micronutrients Panel at Vibrant America Clinical Laboratory. The participants were divided into three groups based on their serum lipid and lipoprotein concentrations: 'Low', 'Normal', and 'High'. The levels of vitamins (A, D, E, and K), minerals (zinc, iron, calcium, and magnesium), and amino acids (leucine, isoleucine, and valine) were measured, and their correlation with cardiovascular markers such as cholesterol, LDL, HDL, and Apo B was analyzed using Pearson's correlation. Results The study found significant associations between micronutrient levels and cardiovascular markers. Vitamins D, E, and K and minerals like zinc, calcium, and magnesium showed positive correlations with lipid markers. Asparagine was negatively correlated with cholesterol and LDL, while amino acids such as isoleucine and valine negatively correlated with HDL but showed a positive association with LDL and Apo B. Fat-soluble vitamins demonstrated strong positive associations with total cholesterol and triglycerides. Conclusion These findings suggest that certain micronutrients play a critical role in regulating lipid profiles and overall cardiovascular health. Further studies are necessary to explore the therapeutic potential of micronutrient supplementation in preventing or managing CVDs.

Indexed as

amino acidsbranched-chain amino acidscardiovascular diseaseslipidsmicronutrientsvitamins

Identifiers

PMID40027047
PMCPMC11872020

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.