Evidence map›Paper›PMID 40027036›Full record

ArticleCureus2025

Crowned Dens Syndrome Presenting as Failure to Thrive in a Patient With Moderate Cognitive Impairment.

Gustavo Castellanos, Gregory L Stone, Amir A Razmjou

Abstract readCase Reports
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Gustavo CastellanosDepartment of Medicine, UCLA Medical Center/David Geffen School of Medicine, Los Angeles, USA.
Gregory L StoneDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, UCLA Medical Center/David Geffen School of Medicine, Los Angeles, USA.
Amir A RazmjouDivision of Rheumatology, Department of Medicine, UCLA Medical Center/David Geffen School of Medicine, Los Angeles, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Crowned dens syndrome (CDS) is a rare condition characterized by the deposition of calcium pyrophosphate (CPP) or hydroxyapatite crystals around the odontoid process of the C2 vertebra, often presenting with acute neck pain, reduced cervical mobility, and systemic inflammatory response. This case describes a 68-year-old male patient with a history of type 2 diabetes, hypertension, and benign prostatic hyperplasia who presented with generalized weakness and failure to thrive. This atypical presentation initially masked symptoms of CDS, delaying the diagnosis until the patient developed acute neck pain and stiffness, prompting further imaging. CT imaging revealed calcifications around the odontoid process, confirming the diagnosis of CDS. Given the severity of the symptoms, corticosteroids were administered, resulting in significant clinical improvement. This case highlights the importance of considering CDS in the differential diagnosis of older patients presenting with systemic inflammatory symptoms and unexplained neck pain, particularly when initial workups are inconclusive.

Indexed as

acute neck pain and stiffnesscalcium pyrophosphate deposition disease (cppd)cervical paincrowned dens syndromeesr (erythrocyte sedimentation rate)recurrent feversteroid tapertransverse ligament

Identifiers

PMID40027036
PMCPMC11870774

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.