Evidence map›Paper›PMID 40026941›Full record

ArticleCureus2025

The Potential Link Between Abdominal Migraine and Chronic Apical Periodontitis: A Case Report.

Fuu Sakai, Kana Ozasa, Kohei Shimizu, Noboru Noma

Abstract readCase Reports
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Fuu SakaiOral Medicine, Nihon University School of Dentistry, Tokyo, JPN.
Kana OzasaOral Medicine, Nihon University School of Dentistry, Tokyo, JPN.
Kohei ShimizuEndodontics, Nihon University School of Dentistry, Tokyo, JPN.
Noboru NomaOral Medicine, Nihon University School of Dentistry, Tokyo, JPN.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

According to the International Classification of Headache Disorders, Third edition (ICHD-3), abdominal migraine is a diagnosis of exclusion, characterized by recurrent abdominal pain accompanied by nausea, vomiting, anorexia, or pallor. We report a case of a 44-year-old female with abdominal migraine associated with chronic apical periodontitis. Treatment with root canal therapy and periodontal management improved both the oral condition and migraine symptoms. Chronic periodontitis may contribute to migraines via systemic inflammation and calcitonin gene-related peptide (CGRP)-mediated neurovascular mechanisms. This case underscores the importance of dental practitioners identifying and managing periodontal conditions to address potential systemic effects and multifactorial orofacial pain.

Indexed as

abdominal migraineapical periodontitischronic periodontitisneurovascular mechanismsorofacial pain

Identifiers

PMID40026941
PMCPMC11872022

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.