ArticlePhysics and imaging in radiation oncology2025
Investigation of 2D anti-scatter grid implementation in a gantry-mounted cone beam computed tomography system for proton therapy.
Article in Physics and imaging in radiation oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Improvement of Soft Tissue Contrast and CT Number Accuracy in Proton Therapy CBCT With Hardware-based Scatter Suppression: Results From a Prospective Trial.International journal of radiation oncology, biology, physics · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Background and purpose: Robust scatter mitigation by 2D anti-scatter grids (2D-ASG) in proton therapy cone beam computed tomography (CBCT) may improve target visualization and computed tomography (CT) number fidelity, allowing online dose verifications and plan adaptations. However, grid artifact-free implementation of 2D-ASG depends on the CBCT system characteristics. Thus, we investigated the feasibility of 2D-ASG implementation in a proton therapy gantry-mounted CBCT system and evaluated its impact on image quality. Materials and methods: A prototype 2D-ASG and a grid support platform were developed for a proton therapy CBCT system with a 340 cm source to imager distance. The effect of gantry flex on 2D-ASG's wall shadows and scan-to-scan reproducibility of 2D-ASG's wall shadows were evaluated. Experiments were conducted to assess 2D-ASG's wall shadow suppression and the effect of 2D-ASG on image quality. Results: While maximum displacement in 2D-ASG wall shadows was 103 µm during gantry rotation, the drift from baseline over 3 months was 8 µm and 1 µm in the transverse and axial directions. 2D-ASG shadows were successfully suppressed in CBCT images. With 2D-ASG, maximum Hounsfield Unit (HU) nonuniformity decreased from 134 to 45 HU, contrast-to-noise ratio (CNR) increased by a factor of 2.5, and HU errors were reduced from 34 % to 5 %. Conclusions: Proton therapy gantry flex was highly reproducible and did not noticeably affect 2D-ASG wall shadow suppression in CBCT images, supporting its feasibility in proton therapy CBCT system. Improved CT accuracy and artifact reduction with 2D-ASG could enhance CBCT-based proton therapy dose calculations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.