ArticlePhysics and imaging in radiation oncology2025
Margins to compensate for respiratory-induced mismatches between lung tumor and fiducial marker positions using four-dimensional computed tomography.
Article in Physics and imaging in radiation oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Intra-respiratory variation in tumour-diaphragm geometric association as a potential surrogate for dynamic tumour-tracking radiotherapy.Physics and imaging in radiation oncology · 2026Article
- First clinical implementation of dynamic tumor-tracking volumetric modulated arc therapy with a gimbal-mounted linac: short delivery time and high precision.Journal of radiation research · 2026Article
- Feasibility of markerless real-time tumor tracking volumetric modulated arc therapy using diaphragm-based respiratory offset vectors.Medical physics · 2025Article
- D-S-Net: an efficient dual-stage strategy for high-precision segmentation of gross tumor volumes in lung cancer CT images.BMC cancer · 2025Article
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10 authors.
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Abstract
Background and purpose: Tumors and fiducial markers do not always exhibit synchronous motion across different respiratory phases, in a phenomenon called the target localization error (TLE). We determined the margin to compensate for the TLE using four-dimensional computed tomography (4D-CT). Materials and methods: We analyzed data from 21 lung tumor patients with fiducial markers; 11 for TLE determination and 10 for validation. Shifted CT images were generated by aligning the centroids of the fiducial markers in the reference phase of 4D-CT with those in each respiratory phase, and the union of gross tumor volumes (GTVs) was determined ( Results: The TLEs (standard deviations of the root mean square error) were 2.0 (0.8) mm, 2.1(0.7) mm, and 3.2 (1.1) mm in the left - right, anterior - posterior, and superior - inferior directions, respectively. A dosimetric evaluation revealed that Conclusion: The TLE can be compensated by adding an anisotropic margin to the GTV in the reference phase, a critical consideration in DTT.
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