Evidence map›Paper›PMID 40026905›Full record

ArticleOsteoarthritis and cartilage open2025

Metabolic syndrome is associated with more pain in hand osteoarthritis: Results from the DIGICOD cohort.

Alix Charton, Romane Lacoste-Badie, Sophie Tuffet, Alexandra Rousseau, Emmanuel Maheu, Bruno Fautrel, Maxime Dougados, Francis Berenbaum, Alice Courties, Jérémie Sellam

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In one paragraph

Article in Osteoarthritis and cartilage open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alix ChartonAssistance Publique - Hôpitaux de Paris (APHP), Sorbonne University, Rheumatology Department, Saint-Antoine Hospital, Paris, France.
Romane Lacoste-BadieAP-HP, Sorbonne University, Clinical Pharmacology Department and Clinical Research Platform of Eastern Paris (URCEST, CRB, CRC), Saint-Antoine Hospital, Paris, France.
Sophie TuffetAP-HP, Sorbonne University, Clinical Pharmacology Department and Clinical Research Platform of Eastern Paris (URCEST, CRB, CRC), Saint-Antoine Hospital, Paris, France.
Alexandra RousseauAP-HP, Sorbonne University, Clinical Pharmacology Department and Clinical Research Platform of Eastern Paris (URCEST, CRB, CRC), Saint-Antoine Hospital, Paris, France.
Emmanuel MaheuAssistance Publique - Hôpitaux de Paris (APHP), Sorbonne University, Rheumatology Department, Saint-Antoine Hospital, Paris, France.
Bruno FautrelAP-HP, Sorbonne University, Rheumatology Department, La Pitié Salpêtrière Hospital, Paris, France.
Maxime DougadosAP-HP, University of Paris, Rheumatology Department, Cochin Hospital, Paris, France.
Francis BerenbaumAssistance Publique - Hôpitaux de Paris (APHP), Sorbonne University, Rheumatology Department, Saint-Antoine Hospital, Paris, France.
Alice CourtiesAssistance Publique - Hôpitaux de Paris (APHP), Sorbonne University, Rheumatology Department, Saint-Antoine Hospital, Paris, France.
Jérémie SellamAssistance Publique - Hôpitaux de Paris (APHP), Sorbonne University, Rheumatology Department, Saint-Antoine Hospital, Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The role of metabolic syndrome (MetS) in osteoarthritis (OA) pain, particularly in non-weight-bearing joints like the hand (HOA), remains debated. This study assessed whether MetS is linked to increased hand pain in patients with HOA. Methods: Using the DIGICOD cohort, 352 HOA patients (85 ​% women, mean age 66.4 ​± ​7.4 years) were analyzed. Pain levels were evaluated via visual analog scale (VAS), AUSCAN pain subscore, and AIMS2 pain subscore. The presence of MetS (Adult Treatment Panel III criteria) and its components were assessed alongside demographic and clinical characteristics, including BMI and radiological severity (KL sum score). Associations were adjusted for confounders (age, sex, KL score, and HAD scale). Outcomes were dichotomized into high/low pain levels, with results expressed as odds ratios (OR) and 95 ​% confidence intervals (CI). Results: MetS was present in 36 ​% of patients and associated with higher pain levels during activity (VAS OR ​= ​1.61, 95 ​% CI 1.02-2.57) and overall OA pain (AIMS2 OR ​= ​1.85, 95 ​% CI 1.14-2.99). Adjusted AUSCAN pain subscore also correlated with MetS (OR ​= ​1.66, 95 ​% CI 1.05-2.62), but significance was reduced when adjusting for HAD (OR ​= ​1.56, 95 ​% CI 0.98-2.48). Elevated triglycerides, a MetS component, were significantly linked to higher AIMS2 pain scores (OR ​= ​2.58, 95 ​% CI 1.09-6.07). BMI was not found to be independently associated with pain. Conclusion: MetS correlates with increased pain in HOA, independent of structural damage and anxiety/depression, underscoring its systemic impact on OA-related pain.

Indexed as

Hand osteoarthritisMetabolic syndromePainPatient-reported outcomes

Identifiers

PMID40026905
PMCPMC11869907

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.