Evidence map›Paper›PMID 40026865›Full record

ArticleJournal of multidisciplinary healthcare2025

Exploring Research Trends and Mechanisms: Maternal Diabetes and Neural Tube Defects (1991-2023).

Lijun Cao, Yujia Xi, Zhinan Jing, Zhuocheng Bao, Bo Bai, Xia Lian, Xiuping Zhang, Jingkai Di, Fan Liu

Abstract read
In one paragraph

Article in Journal of multidisciplinary healthcare, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lijun Cao *Department of Neurology, Second Hospital of Shanxi Medical University, Taiyuan, People's Republic of China.
Yujia Xi *Department of Urology, Second Hospital of Shanxi Medical University, Taiyuan, People's Republic of China.ORCID 0000-0002-2590-2428
Zhinan Jing *Male Reproductive Health Research Center, Shanxi Medical University, Jinzhong, Shanxi, People's Republic of China.ORCID 0009-0005-5436-9246
Zhuocheng BaoMale Reproductive Health Research Center, Shanxi Medical University, Jinzhong, Shanxi, People's Republic of China.
Bo BaiDepartment of Neurology, Second Hospital of Shanxi Medical University, Taiyuan, People's Republic of China.
Xia LianDepartment of Neurology, Second Hospital of Shanxi Medical University, Taiyuan, People's Republic of China.
Xiuping ZhangDepartment of Neurology, Second Hospital of Shanxi Medical University, Taiyuan, People's Republic of China.
Jingkai DiDepartment of Orthopedics, Second Hospital of Shanxi Medical University, Taiyuan, People's Republic of China.
Fan LiuDepartment of Neurology, Second Hospital of Shanxi Medical University, Taiyuan, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Neural tube defect (NTD) is the second most common congenital neuropathy in the world. Maternal diabetes is an important factor leading to the occurrence of NTD in offspring. However, existing studies lack a systematic analysis of the correlation between maternal diabetes and NTDs, as well as an exploration of NTD pathogenesis and associated preventive strategies. Consequently, there is a need for a thorough examination of the literature pertaining to NTDs and maternal diabetes to elucidate a comprehensive understanding, identify research focal points, and anticipate future developmental trends. Methods: The literature related to NTDs and maternal diabetes from 1991 to 2023 was retrieved from the Web of Science Core Collection (WoSCC). Bibliometric software CiteSpace (version 6.2.6) was used for co-occurrence/citation network analysis and to draw a knowledge visualization map. Results: A total of 382 articles and reviews were included in the final analysis. Findings revealed an increasing trend in annual publication rates. The University of Maryland Baltimore emerged as the institution with the highest number of publications, while the American Journal of Obstetrics and Gynecology and Birth Defects Research Part A-Clinical and Molecular Teratology stood out as the most prolific research journals. EA Reece was identified as the leading contributor in this domain. The United States emerged as the global leader in this field, making the most significant contribution to research endeavors. The cluster analysis of keywords obtained eight clusters, and the research focus was on the pathogenesis of NTDs induced by maternal diabetes. Conclusion: This study employed bibliometric methods to visualize the research landscape of NTDs induced by maternal diabetes, aiming to comprehend trends and identify key areas of interest in this domain. By studying the relevant mechanisms, we will search for new key targets. Meanwhile, future research needs to further explore new treatment strategies.

Indexed as

bibliometric analysisCiteSpacecluster analysesdiabetesneural tube defectsresearch hotspotsvisualizationVOSviewer

Identifiers

PMID40026865
PMCPMC11871925

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.