Evidence map›Paper›PMID 40026717›Full record

ArticleJournal of anaesthesiology, clinical pharmacology

Impact of anesthetic induction with etomidate, thiopentone, and propofol on regional cerebral oxygenation: An observational study in patients with traumatic brain injury.

Kunal K Sharma, Rohini M Surve, K R Madhusudan Reddy, Rita Christopher, Dhritiman Chakrabarti, Sundaravadivel Pandarisamy, Shruti V Palakuzhiyil, Sriganesh Kamath

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Article in Journal of anaesthesiology, clinical pharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Kunal K SharmaDepartment of Neruroanesthesia and Neurocritical Care, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.
Rohini M SurveDepartment of Neruroanesthesia and Neurocritical Care, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.
K R Madhusudan ReddyDepartment of Neruroanesthesia and Neurocritical Care, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.
Rita ChristopherDepartment of Neurovirology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.
Dhritiman ChakrabartiDepartment of Neruroanesthesia and Neurocritical Care, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.
Sundaravadivel PandarisamyDepartment of Neurovirology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.
Shruti V PalakuzhiyilDepartment of Neurovirology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.
Sriganesh KamathDepartment of Neruroanesthesia and Neurocritical Care, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Aims: Anesthetic induction plays a pivotal role in determining the operative course and the outcome in patients with acute traumatic brain injury (TBI). The present study compared the effect of anesthetic induction with etomidate, thiopentone, and propofol primarily on systemic hemodynamics and regional cerebral oxygenation (rScO Material and Methods: In this prospective observational study, eligible patients were recruited and divided into three groups as per the induction agent received. Data collected were hemodynamic parameters and rScO Results: A total of 115 patients were included: 32, 33, and 50 in thiopentone, propofol, and etomidate groups, respectively. A significant increase ( Conclusions: In TBI patients, anesthetic induction with etomidate resulted in least hemodynamic changes compared to induction with thiopentone and propofol. The rScO

Indexed as

Blood pressurecerebral oxygen saturationcortisoletomidateKey Messages: Anesthetic induction with etomidate produced least hemodynamic changes compared to induction with thiopentone and propofol in patients with traumatic brain injury. Consequently, maximal increase in cerebral oxygen saturation occurred with etomidate among the three induction agents. An insignificant decrease in serum cortisol was observed with etomidate and thiopentone, but not with propofol. Neurological outcome at discharge was similar with all drugs.propofolthiopentonetraumatic brain injury

Identifiers

PMID40026717
PMCPMC11867366

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