Evidence map›Paper›PMID 40026700›Full record

ArticleGastro hep advances2025

A Comprehensive Assessment of Liver Transplant Trends and Outcomes Among Adults With Steatotic Liver Disease in the U.S.

Shyam Patel, Sohil Patel, Wei Zhang, Ashwani K Singal, Ramsey Cheung, Robert J Wong

Abstract read
In one paragraph

Article in Gastro hep advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shyam PatelDepartment of Medicine, California Pacific Medical Center, San Francisco, California.
Sohil PatelSchool of Medicine, University of California, San Francisco, California.
Wei ZhangGastroenterology Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Ashwani K SingalDivision of Gastroenterology, Hepatology and Nutrition, University of Louisville School of Medicine, Transplant Hepatology, UofL Health Jewish Hospital and Trager Transplant Center, Rob Rexley VA Medical Center, Louisville, Kentucky.
Ramsey CheungDivision of Gastroenterology and Hepatology, Department of Medicine, Stanford University School of Medicine, Palo Alto, California.
Robert J WongDivision of Gastroenterology and Hepatology, Department of Medicine, Stanford University School of Medicine, Palo Alto, California.

Funding

Racial and Ethnic Disparities in Hepatocellular Carcinoma Surveillance Among Patients with Cirrhosis Across Five Safety Net OrganizationsR01MD017063 · NIMHD · PALO ALTO VETERANS INSTIT FOR RESEARCH · PI Robert John Wong · 2022 to 2026
$2.8M
NIMHD NIH HHS R01 MD017063
6 · The paper itself

Abstract

Background and Aims: Steatotic liver disease (SLD) is the leading indication for liver transplantation (LT) among U.S. adults. We aim to provide comprehensive updates of LT trends and outcomes among adults with SLD, highlighting racial, ethnic, and sociodemographic disparities. Methods: Using data from the 2010 to 2023 United Network for Organ Sharing registry, we performed a retrospective cohort study evaluating LT waitlist trends, waitlist outcomes, and post-LT survival among 65,675 adults with SLD. Disparities in LT outcomes were evaluated using adjusted competing risks analyses. Results: From 2014 to 2023, there was an increasing proportion of Hispanics, women, and younger adults with SLD listed for LT. For Hispanics, this was driven by metabolic dysfunction-associated steatohepatitis (MASH); 19.9% of MASH wait-listings in 2023 were Hispanics. For women and younger adults (18-39 years), this was driven by alcohol-associated liver disease (ALD); 30.9% and 16.4% of ALD-related wait-listings in 2023 were women and younger adults, respectively. Women (vs men) had greater waitlist removal risk (subdistribution hazard ratio (sHR) 1.12, 95% confidence interval (CI) 1.07-1.18) and lower likelihood of LT receipt (sHR 0.87, 95% CI, 0.85-0.90). Ethnic minorities had worse outcomes, particularly Hispanics, who had a 37% higher risk of waitlist removal (sHR 1.37, 95% CI, 1.30-1.45) and 16% lower likelihood of LT receipt (sHR 0.86, 95% CI, 0.82-0.87) vs non-Hispanic whites. Disparities in post-LT survival were also observed. Conclusion: In 2023, nearly one-quarter of MASH liver transplant waitlist registrants were Hispanics. Approximately half and 1 in 6 ALD waitlist registrants were women and younger adults, respectively. These concerning trends are amplified by the disparities in LT outcomes observed among women and ethnic minorities.

Indexed as

Alcohol-Associated Liver DiseaseMetabolic Dysfunction–Associated SteatohepatitisMetabolic Dysfunction–Associated Steatotic Liver DiseaseUNOS

Identifiers

PMID40026700
PMCPMC11869966

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.