Evidence map›Paper›PMID 40026599›Full record

ReviewTransplant international : official journal of the European Society for Organ Transplantation2025

Heart Transplantation and Donation After Circulatory Death in Children. A Review of the Technological, Logistical and Ethical Framework.

Louise Amelia Kenny, Liz Armstrong, Marius Berman, Joe Brierley, David Crossland, John Dark, Dale Gardiner, Stephen Ralph Large, Derek Manas, Mohamed Nassar and 2 more

Abstract readReview
In one paragraph

Review in Transplant international : official journal of the European Society for Organ Transplantation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Modeling the cost-effectiveness of introducing donation after controlled circulatory death for heart transplantation in France.Transplant international : official journal of the European Society for Organ Transplantation · 2026
    Article
  5. Transplant International: Looking Back at 2025, Looking Forward to 2026.Transplant international : official journal of the European Society for Organ Transplantation · 2026
    Article
  6. Article
  7. cDCDD and Heart Procurement: Challenges from a French Critical Care Perspective.Transplant international : official journal of the European Society for Organ Transplantation · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Louise Amelia KennyPaediatric Heart Unit, Institute of Transplantation, Freeman Hospital, Newcastle upon Tyne, United Kingdom.
Liz ArmstrongNational Health Service Blood and Transplant, Bristol, United Kingdom.
Marius BermanNational Health Service Blood and Transplant, Bristol, United Kingdom.
Joe BrierleyPaediatric Intensive Care Unit, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom.
David CrosslandPaediatric Heart Unit, Institute of Transplantation, Freeman Hospital, Newcastle upon Tyne, United Kingdom.
John DarkTranslational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, England, United Kingdom.
Dale GardinerNational Health Service Blood and Transplant, Bristol, United Kingdom.
Stephen Ralph LargeDepartment of Cardiothoracic Surgery, Papworth Hospital NHS Foundation Trust, Cambridge, United Kingdom.
Derek ManasPaediatric Heart Unit, Institute of Transplantation, Freeman Hospital, Newcastle upon Tyne, United Kingdom.
Mohamed NassarPaediatric Heart Unit, Institute of Transplantation, Freeman Hospital, Newcastle upon Tyne, United Kingdom.
David ShawInstitute of Biomedical Ethics, University of Basel, Basel, Switzerland.
Emma SimpsonPaediatric Heart Unit, Institute of Transplantation, Freeman Hospital, Newcastle upon Tyne, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heart transplant for adults following Donation after Circulatory Death (DCD) is well established in many parts of the world, including the United Kingdom (UK). Small child DCD hearts have now been recovered in the UK and internationally utilising novel technologies. Despite these recent advances, extension of this practice to pediatric cardiac transplantation has been slow and difficult despite the severe shortage of donors for children leading to a high number of deaths annually of children waiting for heart transplant. This is in direct contrast with the thriving UK programme of adult DCD heart transplant and pediatric DCD donation for non-cardiac organs. There has been insufficient action in addressing this inequality thus far. Barriers to development of a pediatric cardiac DCD programme are multifaceted: ethical concerns, technological paucity, financial and logistical hurdles. We describe the background, live issues, current developments and how we are driving resources toward a sustainable DCD programme for small children in the UK to provide valuable insights to other countries of the elements and principles at play. This is a call to responsible bodies to take urgent and achievable actions to establish an equitable paediatric DCD cardiac programme for donors, recipients and their families.

Indexed as

Heart TransplantationTissue and Organ ProcurementTissue DonorsChildChild, PreschoolDeathHumansUnited Kingdomdonation after circulatory death (DCD)ex-situ heart perfusionhypothermic organ perfusionpediatric heart transplantationpediatric organ donation

Identifiers

PMID40026599
PMCPMC11867792

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.