Evidence map›Paper›PMID 40026562›Full record

ArticleThe journal of liquid biopsy2024

Unlocking the promise of liquid biopsies in precision oncology.

Alejandra Pando-Caciano, Rakesh Trivedi, Jarne Pauwels, Joanna Nowakowska, Beatrice Cavina, Lovisa Falkman, Jessica Debattista, Szilárd-Krisztián Belényesi, Periyasamy Radhakrishnan, Mariano A Molina

Abstract read
In one paragraph

Article in The journal of liquid biopsy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alejandra Pando-CacianoDepartment of Cellular and Molecular Sciences, Universidad Peruana Cayetano Heredia, Av. Honorio Delgado 430, San Martín de Porres, Lima, 15102, Peru.
Rakesh TrivediDepartment of Cancer Biology, Mayo Clinic, Scottsdale, AZ, USA.
Jarne PauwelsVIB-UGent Center for Medical Biotechnology, VIB, 9052, Ghent, Belgium.
Joanna NowakowskaMolecular and Cell Biology Unit, Department of Pediatric Pulmonology, Allergy and Clinical Immunology, Poznan University of Medical Sciences, Poznan, Poland.
Beatrice CavinaDepartment of Medical and Surgical Sciences (DIMEC), Centro di Studio e Ricerca sulle Neoplasie (CSR) Ginecologiche, Alma Mater Studiorum-University of Bologna, 40138, Bologna, Italy.
Lovisa FalkmanDepartment of Medical Sciences, Endocrine Tumor Biology, Uppsala University Hospital, Uppsala University, Uppsala, Sweden.
Jessica DebattistaPathology Department, Faculty of Medicine and Surgery, University of Malta, Malta.
Szilárd-Krisztián BelényesiSchool of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Ireland.
Periyasamy RadhakrishnanDepartment of Medical Genetics, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, 576104, Karnataka, India.
Mariano A MolinaDepartment of Pathology, Vrije Universiteit Amsterdam, Amsterdam UMC Location VUmc, Amsterdam, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liquid biopsies have emerged as a promising and minimally invasive alternative to traditional tissue biopsies for detecting and monitoring cancer. Liquid biopsies offer a comprehensive analysis of cancer genetics and tumor burden by examining circulating cells and cell-derived analytes using a variety of assays, including conventional PCR methods and cutting-edge tools like long-read sequencing and nanotechnology. However, there are still some limitations and challenges that need to be overcome for their implementation in clinical routine, including the need for further research on their sensitivity and specificity, cost-effectiveness, standardization, and regulatory approval. Despite these challenges, liquid biopsies have the potential to become widely used tools in oncology. Here we provide an overview of the current state of liquid biopsies, highlighting recent advancements in the field and their potential benefits in clinical settings for cancer patients. The article further discusses the challenges that need to be addressed in order to facilitate their application worldwide. Prompt resolution of these challenges can be achieved by fostering international research collaborations and establishing standardized guidelines for liquid biopsy sample management and studies.

Indexed as

BiomarkerCancerClinical implementationLiquid biopsyPrecision oncologyStandardization

Identifiers

PMID40026562
PMCPMC11863887

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.