Evidence map›Paper›PMID 40026543›Full record

ArticleF1000Research2025

A Randomized Controlled Trial Evaluating the Effect of Local Application of Sodium Alendronate Gel and Low-Level Laser Therapy (LLLT) On Peri-Implant Tissue Healing in Wistar Rats.

Divya Mishra, Arun S Urala, Ashwath S Nayak, Divya S, Rajay Kamath, Lakshmi Narayan Bairy, Gargi S

Abstract read
In one paragraph

Article in F1000Research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Divya Mishra *Department of Orthodontics and Dentofacial Orthopaedics, Manipal College of Dental Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.
Arun S UralaDepartment of Orthodontics and Dentofacial Orthopaedics, Manipal College of Dental Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.
Ashwath S NayakDepartment of Orthodontics and Dentofacial Orthopaedics, Bapuji Dental College and Hospital, Davanagere, Karanataka, 577004, India.ORCID https://orcid.org/0000-0002-8029-6002
Divya S *Department of Orthodontics and Dentofacial Orthopaedics, Manipal College of Dental Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.ORCID https://orcid.org/0000-0001-8957-8914
Rajay KamathDepartment of Clinical Genomics, Mayo Clinic Minnesota, Rochester, Minnesota, USA.
Lakshmi Narayan BairyDepartment of Pharmacology, RAK College of Medical Sciences, RAK Medical and Health Sciences University, Ra's Al Khaimah, United Arab Emirates.ORCID https://orcid.org/0000-0002-1828-6946
Gargi SDepartment of Orthodontics and Dentofacial Orthopaedics, Manipal College of Dental Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.

Funding

Mechanism of ephrin signaling in mammalian palatal fusionR01DE022804 · NIDCR · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI BENSON, M. DOUGLAS · 2014 to 2018
$2.3M
NIDCR NIH HHS R01 DE022804
6 · The paper itself

Abstract

Objective: To evaluate the effect of local application of Sodium Alendronate incorporated in Carbapol gel together with LLLT on peri-implant tissue healing in Wistar rat femurs. Methods: Twenty-four male Wistar rats were randomly divided into 4 groups: Group 1 (the control group), Group 2 (the Sodium Alendronate group), Group 3 (the Sodium Alendronate and LLLT group), and Group 4 (the LLLT group). Mini implants were placed in right and left femur bones in all the four groups. Implants of groups 2 and 3 were coated in 1mg Carbapol gel incorporated with 1 mg Sodium alendronate. Groups 3 and 4 were exposed to LLLT (CO Results: Groups 3 and 4 showed bony union and formation of reorganized spongiosa whereas Groups 1 and 2 showed fibrous union. The bone marrow from Group 3 had an adult-type fatty marrow, while that from Group 2 and 4 was occupied by red blood cells. Group 1 showed initial stages of bone healing in which the defect occupied more than half of the bone marrow. Conclusion: LLLT given using CO

Indexed as

AlendronateLow-Level Light TherapyWound HealingAnimalsFemurGelsMaleRatsRats, WistarAlendronateGelsanchorageanimal studybisphosphonatesLow level laser therapyMicro-implantsphoto-biomodulation

Identifiers

PMID40026543
PMCPMC11868745

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.