Evidence map›Paper›PMID 40026516›Full record

ArticleReviews in cardiovascular medicine2025

Effects of Prediabetes on Ventricular Repolarization Markers in Electrocardiography.

Tolga Memioğlu, Mehmet İnanır, Kenan Toprak, Müjgan Gürler

Abstract read
In one paragraph

Article in Reviews in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Tolga MemioğluFaculty of Medicine, Bolu Abant Izzet Baysal University, 14030 Bolu, Turkey.ORCID https://orcid.org/0000-0002-3183-5815
Mehmet İnanırFaculty of Medicine, Bolu Abant Izzet Baysal University, 14030 Bolu, Turkey.ORCID https://orcid.org/0000-0003-1784-3584
Kenan ToprakFaculty of Medicine, Harran University, 63050 Sanliurfa, Turkey.ORCID https://orcid.org/0000-0001-8923-8709
Müjgan GürlerFaculty of Medicine, Bolu Abant Izzet Baysal University, 14030 Bolu, Turkey.ORCID https://orcid.org/0000-0001-9532-8241

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The blood glucose levels in people with prediabetes mellitus (PDM) are regarded as too high to be normal but below the cutoff for diabetes mellitus (DM). Clinical indicators for PDM patients include impaired glucose tolerance (IGT), impaired fasting glucose (IFG), and/or hemoglobin A1c (HbA1c) levels between 5.7 and 6.4% (39-47 mmol/mol). PDM has been shown to raises the risk of cardiovascular disease (CVD) and mortality. Meanwhile, death and morbidity can be predicted by the new ventricular repolarization features of the electrocardiogram (ECG). Several studies have analyzed the connection between DM and the ventricular repolarization characteristics of ECG; however, few studies have examined the connection between PDM and these ventricular repolarization characteristics. This study evaluated the ECG ventricular repolarization parameters in individuals with PDM. Methods: A retrospective case-control design was used. Randomly selected participants included 79 PDM patients (30 men, mean age: 39.7 ± 5.7 years) and 79 controls (30 men, mean age: 39.8 ± 5.2 years). ECG intervals analyzed were the distance from the beginning of the Q wave to the end of the T wave (QT), the distance between Q and S waves (QRS), the distance between the T wave's termination and point J (JT), and the distance between the peak and endpoint of the T wave (Tp-e), along with corrected and derived measures (corrected QT interval (QTc), the difference between the maximum and smallest QT intervals (QTd), corrected QTd (QTdc), corrected JT interval (JTc), Tp-e/QT, Tp-e/QTc, Tp-e/JT, Tp-e/JTc). Patient records were retrieved from the institution's database. Results: Both groups had comparable averages for age, gender, smoking, hyperlipidemia, body mass index (BMI), ( Conclusions: In our study, the HbA1c value was shown to be moderately positively correlated with the heart rate and QTc, QTd, QTdc, JTc, and Tp-e intervals, all of which were determined to be significant. Additionally, the HbA1c value showed a weak positive correlation with Tp-e/QT, Tp-e/JT ratios, which were statistically significant. This study showed that patients with PDM are prone to ventricular arrhythmia in the early period of the disorder.

Indexed as

arrhythmiaelectrocardiographyprediabetesrepolarization markerTp-e interval

Identifiers

PMID40026516
PMCPMC11868905

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.