Trial reportJournal of cosmetic dermatology2025
An Evaluation of VYC-17.5L for Forehead Contouring: A Prospective, Open-Label, Post-Marketing Study.
Trial report in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- VYC-17.5L is Safe and Effective in Improving Skin Quality and Volume Deficit of Hands: Results From an 18-Month Open-Label Study.Journal of cosmetic dermatology · 2026Article
- Enhancing Mid-Upper Facial Contours: Hairline Transplant Solutions for East Asian Women With High and Wide Foreheads.Journal of cosmetic dermatology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundForehead contouring can be achieved using injectable fillers. VYC-17.5L is a filler containing 17.5 mg/mL of hyaluronic acid (HA) with lidocaine (3 mg/mL) for the treatment of skin depressions due to premature aging. Prior studies have demonstrated the safety and efficacy of VYC-17.5L in nasolabial folds, lips, and radial cheek lines, but little has been published on the effectiveness of VYC17.5L for forehead contouring.
aimsThis prospective, open-label, post-marketing study conducted in France evaluated the effectiveness and safety of the HA injectable filler VYC-17.5L for use in forehead contouring.
methodsAdults (≥ 18 years) with irregularities of forehead contouring received VYC-17.5L in the forehead on Day 1 with an optional touch-up on Day 14. Effectiveness was assessed via investigator-rated Global Aesthetic Improvement Scale (GAIS) of "improved" or "much improved" from baseline at month 1 (M1). Secondary endpoints included participant-rated GAIS and FACE-Q Satisfaction with Facial Appearance. Injection site reactions (ISRs) and adverse device effects (ADEs) were assessed throughout the study.
resultsEighty subjects completed the study. The primary endpoint was met: 97.5% of participants showed improvement on the investigator GAIS. Participant GAIS scores were also improved. FACE-Q scores significantly improved from baseline (p < 0.0001) and were sustained through month 12. Most ISRs were mild or moderate and resolved in ~1 week. Nine subjects (11%) reported ADEs, with the majority being mild or moderate; the most common ADE was pain, which resolved in < 15 days.
conclusionVYC-17.5L was well tolerated and effective for improving forehead contouring, as demonstrated by improvements in investigator- and participant-rated measures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.