Evidence map›Paper›PMID 40026256›Full record

ArticleFEBS letters2025

Taurine promotes glucagon-like peptide-1 secretion in enteroendocrine L cells.

Yuri Osuga, Kazuki Harada, Takuya Yamauchi, Tetsuya Kitaguchi, Masami Yokota Hirai, Mitsuharu Matsumoto, Takashi Tsuboi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FEBS letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yuri OsugaDepartment of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Meguro, Japan.
Kazuki HaradaDepartment of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Meguro, Japan.
Takuya YamauchiDepartment of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Meguro, Japan.
Tetsuya KitaguchiLaboratory for Chemistry and Life Science, Institute of Integrated Research, Institute of Science Tokyo, Yokohama, Japan.
Masami Yokota HiraiRIKEN Center for Sustainable Resource Science, Yokohama, Japan.
Mitsuharu MatsumotoDairy Science and Technology Institute, Kyodo Milk Industry Co., Ltd., Tokyo, Japan.
Takashi TsuboiDepartment of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Meguro, Japan.ORCID https://orcid.org/0000-0001-8290-2021

Funding

Japan Society for the Promotion of Science 23H03303Japan Society for the Promotion of Science 23KJ0612The Uehara Memorial Foundation
6 · The paper itself

Abstract

Taurine, an amino-sulfonic acid mainly sourced from food, suppresses blood glucose by stimulating insulin secretion from pancreatic β-cells. However, its relationship with glucagon-like peptide-1 (GLP-1) secretion from enteroendocrine L cells is unclear. This study aimed to determine the role of taurine in GLP-1 secretion from L cells. Taurine administration promoted GLP-1 secretion in enteroendocrine L cell line GLUTag cells and increased plasma GLP-1 in mice. Taurine uptake via the taurine transporter increased cytosolic ATP levels, resulting in higher intracellular Ca

Indexed as

Enteroendocrine CellsGlucagon-Like Peptide 1TaurineAdenosine TriphosphateAnimalsCalciumCell LineKATP ChannelsMaleMembrane GlycoproteinsMembrane Transport ProteinsMiceMice, Inbred C57BLTaurine TransportersAdenosine TriphosphateCalciumGlucagon-Like Peptide 1KATP ChannelsMembrane GlycoproteinsMembrane Transport ProteinsTaurineTaurine Transportersglucagon‐like peptide‐1GLUTaglive‐cell imagingtaurinetaurine transporter

Identifiers

PMID40026256
PMCPMC12147438

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.