Evidence map›Paper›PMID 40026233›Full record

ArticleThe Journal of pathology2025

Multiomic spatial atlas shows deleted in malignant brain tumors 1 (DMBT1) glycoprotein is lost in colonic dysplasia.

Emily H Green, Subhag R Kotrannavar, Megan E Rutherford, Hannah M Lunnemann, Harsimran Kaur, Cody N Heiser, Hua Ding, Alan J Simmons, Xiao Liu, D Borden Lacy and 8 more

Abstract read
In one paragraph

Article in The Journal of pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Emily H GreenDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
Subhag R KotrannavarDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Megan E RutherfordDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Hannah M LunnemannEpithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Harsimran KaurEpithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Cody N HeiserEpithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0002-1299-1628
Hua DingDepartment of Microbiology and Molecular Immunology, Bloomberg School of Public Health, Baltimore, MD, USA.
Alan J SimmonsEpithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Xiao LiuDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.
D Borden LacyDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
M Kay WashingtonDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
Martha J ShrubsoleVanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Qi LiuEpithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Ken S LauEpithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Cynthia L SearsDepartment of Microbiology and Molecular Immunology, Bloomberg School of Public Health, Baltimore, MD, USA.
Robert J CoffeyEpithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Julia L Drewes *Department of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Nicholas O Markham *Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0002-1348-1267

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI STACIE B DUSETZINA · 1995 to 2026
$172.8M
Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9M
Vanderbilt-Ingram Cancer Center SPORE in Gastrointestinal CancerP50CA236733 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Robert J. Coffey · 2019 to 2026
$19.6M
Shaping the Microenvironment by DPEP1 Facilitates Adenoma ProgressionU54CA274367 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Martha J. Shrubsole · 2022 to 2026
$9.7M
Integrated approach to study early and late events in colonic neoplasia: mouse to manR35CA197570 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Robert J. Coffey · 2017 to 2026
$9.4M
Structural Mechanisms of Clostridioides difficile pathogenesisR37AI095755 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Dana Borden Lacy · 2021 to 2026
$3.2M
Characterization of microbial and host requirements for colonic biofilm assembly and biofilm-mediated colon tumorigenesisR00CA230192 · NCI · JOHNS HOPKINS UNIVERSITY · PI DREWES, JULIA L · 2020 to 2022
$747k
Deleted in malignant brain tumors 1 (DMBT1) expression and impact on colonic dysplasiaF31CA294983 · NCI · VANDERBILT UNIVERSITY · PI Emily H Green · 2024 to 2026
$105k
BLRD VA I01 BX002943BLRD VA IK2 BX005699NCI NIH HHS F31 CA294983NCI NIH HHS P30 CA068485NCI NIH HHS P30CA068485NCI NIH HHS P50 CA236733NCI NIH HHS P50CA236733NCI NIH HHS R00 CA230192NCI NIH HHS R00CA230192NCI NIH HHS R35 CA197570NCI NIH HHS U54 CA274367NIAID NIH HHS R37 AI095755NIDDK NIH HHS P30 DK058404NIDDK NIH HHS P30DK058404Veterans Administration Medical Center BX002943Veterans Administration Medical Center BX005699
6 · The paper itself

Abstract

Colorectal cancer (CRC) is responsible for over 900,000 annual deaths worldwide. Emerging evidence supports pro-carcinogenic bacteria in the colonic microbiome are at least promotional in CRC development and may be causal. We previously showed toxigenic C. difficile from human CRC-associated bacterial biofilms accelerates tumorigenesis in Apc

Indexed as

Calcium-Binding ProteinsColonColorectal NeoplasmsDNA-Binding ProteinsAnimalsClostridioides difficileGastrointestinal MicrobiomeGene Expression Regulation, NeoplasticHumansMiceMice, Inbred C57BLTranscriptomeTumor Suppressor ProteinsCalcium-Binding ProteinsDMBT1 protein, humanDNA-Binding ProteinsTumor Suppressor Proteinscolorectalcolorectal adenocarcinomamicrobiometumorigenesis

Identifiers

PMID40026233
PMCPMC11985286

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.