ArticleDevelopment (Cambridge, England)2025
Mechanical strain focusing at topological defect sites in regenerating Hydra.
Article in Development (Cambridge, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- A flexible repertoire of wound closure strategies precedes whole-body regeneration.Nature communications · 2026Article
- The dual nature of body-axis formation in Hydra regeneration: Polarity-morphology concurrency.Biophysical journal · 2026Article
- Multi-phase field model reveals internal dissipation is crucial for spontaneous hole formation in cell monolayers.Nature communications · 2026Article
- Mutual inhibition model of pattern formation: The role of Wnt-Dickkopf interactions in driving Hydra body axis formation.PLoS computational biology · 2026Article
- Modeling mechanochemical coupling in optogenetically activated cell layers.Biophysical journal · 2026Article
- Nematic cell alignment directs calcium waves in an epithelial monolayer.Biophysical journal · 2026Article
- Emergent stable tissue shapes from the regulatory feedback between morphogens and cell growth.Journal of theoretical biology · 2026Article
- Nematic cell alignment directs calcium waves.bioRxiv : the preprint server for biology · 2025Article
- Capturing nematic order on tissue surfaces of arbitrary geometry.Nature communications · 2025Article
- Anisotropic stretch biases the self-organization of actin fibers in multicellular Hydra aggregates.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Emergent Stable Tissue Shapes from the Regulatory Feedback between Morphogens and Cell Growth.bioRxiv : the preprint server for biology · 2025Article
- IsJournal of developmental biology · 2025Review
- Mechanochemical patterning localizes the organizer of a luminal epithelium.Science advances · 2025Article
- Topology changes ofScience advances · 2025Article
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Authors and funding
9 authors.
Funding
Abstract
The formation of a new head during Hydra regeneration involves the establishment of a head organizer that functions as a signaling center and contains an aster-shaped topological defect in the organization of the supracellular actomyosin fibers. Here, we show that the future head region in regenerating tissue fragments undergoes multiple instances of extensive stretching and rupture events from the onset of regeneration. These recurring localized tissue deformations arise due to transient contractions of the supracellular ectodermal actomyosin fibers that focus mechanical strain at defect sites. We further show that stabilization of aster-shaped defects is disrupted by perturbations of the Wnt signaling pathway. We propose a closed-loop feedback mechanism promoting head organizer formation, and develop a biophysical model of regenerating Hydra tissues that incorporates a morphogen source activated by mechanical strain and an alignment interaction directing fibers along morphogen gradients. We suggest that this positive-feedback loop leads to mechanical strain focusing at defect sites, enhancing local morphogen production and promoting robust organizer formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.