Evidence map›Paper›PMID 40026172›Full record

ArticleCirculation. Cardiovascular imaging2025

Echocardiographic Characterization of Myocardial Stiffness in Healthy Volunteers, Cardiac Amyloidosis, and Hypertrophic Cardiomyopathy: A Case-Control Study Using Multimodality Imaging.

Dominik C Benz, Ali Sadeghi, Pat G Rafter, Olivier F Clerc, Jocelyn Canseco Neri, Alexandra Taylor, Shilpa Vijayakumar, Carolyn Y Ho, Sarah A M Cuddy, Rodney H Falk and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Cardiovascular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Dominik C BenzCardiovascular Imaging and Amyloidosis Programs (D.C.B., O.F.C., J.C.N., A.T., S.V., S.A.M.C., R.H.F., S.D.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.ORCID 0000-0001-8627-726X
Ali SadeghiPhilips Research, Cambridge, MA (A.S., P.R.).ORCID 0009-0004-0086-6039
Pat G RafterPhilips Research, Cambridge, MA (A.S., P.R.).
Olivier F ClercCardiovascular Imaging and Amyloidosis Programs (D.C.B., O.F.C., J.C.N., A.T., S.V., S.A.M.C., R.H.F., S.D.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.ORCID 0000-0001-7725-9318
Jocelyn Canseco NeriCardiovascular Imaging and Amyloidosis Programs (D.C.B., O.F.C., J.C.N., A.T., S.V., S.A.M.C., R.H.F., S.D.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Alexandra TaylorCardiovascular Imaging and Amyloidosis Programs (D.C.B., O.F.C., J.C.N., A.T., S.V., S.A.M.C., R.H.F., S.D.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Shilpa VijayakumarCardiovascular Imaging and Amyloidosis Programs (D.C.B., O.F.C., J.C.N., A.T., S.V., S.A.M.C., R.H.F., S.D.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Carolyn Y HoCardiovascular Division (C.Y.H.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.ORCID 0000-0002-7334-7924
Sarah A M CuddyCardiovascular Imaging and Amyloidosis Programs (D.C.B., O.F.C., J.C.N., A.T., S.V., S.A.M.C., R.H.F., S.D.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.ORCID 0000-0002-2124-2151
Rodney H FalkCardiovascular Imaging and Amyloidosis Programs (D.C.B., O.F.C., J.C.N., A.T., S.V., S.A.M.C., R.H.F., S.D.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Sharmila DorbalaCardiovascular Imaging and Amyloidosis Programs (D.C.B., O.F.C., J.C.N., A.T., S.V., S.A.M.C., R.H.F., S.D.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.ORCID 0000-0003-1462-1185

Funding

Noninvasive Cardiovascular Imaging Research Training ProgramT32HL094301 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Marcelo F DI CARLI · 2010 to 2026
$7.8M
Interplay of Myocardial Fibrosis and Cardiac TTR Amyloid in Age Related Cardiac Remodeling in MESA-Multi-Ethnic Study of AtherosclerosisR01HL159987 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI DORBALA, SHARMILA, LIMA, JOAO A C · 2022 to 2025
$5.6M
Early Detection of Transthyretin Cardiac Amyloidosis: Defining a Novel Target for HFpEF Treatment and Prevention in Late LifeR01HL150342 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI DORBALA, SHARMILA, SHAH, AMIL M · 2020 to 2023
$4.1M
Mentoring Patient Oriented Research in Innovative Imaging and High-dimensional Data Approaches to Improve Outcomes in Cardiac AmyloidosisK24HL157648 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI DORBALA, SHARMILA · 2021 to 2025
$612k
Elucidating Mechanisms of Cardiac Dysfunction Using Imaging and ProteomicsK99HL175107 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CLERC, OLIVIER FLORIAN · 2024 to 2025
$214k
NHLBI NIH HHS K24 HL157648NHLBI NIH HHS K99 HL175107NHLBI NIH HHS R01 HL150342NHLBI NIH HHS R01 HL159987NHLBI NIH HHS T32 HL094301
6 · The paper itself

Abstract

backgroundNoninvasive tools to measure myocardial stiffness are limited. Intrinsic cardiac elastography in echocardiography relates to myocardial stiffness by measuring the propagation of the myocardial stretch generated by atrial contraction. The aims of the present study were (1) to evaluate myocardial stiffness using intrinsic cardiac elastography in healthy volunteers versus those with myocardial diseases (ie, cardiac amyloidosis [CA] and hypertrophic cardiomyopathy) and (2) to identify key factors that affect myocardial stiffness.

methodsIn this prospective study, myocardial stiffness was estimated in 54 participants, including 10 hypertrophic cardiomyopathy, 28 CA, and 16 healthy volunteers. Myocardial stiffness was assessed as intrinsic velocity propagation of myocardial stretch (iVP, m/s) measured by high frame rate echocardiography (ie, above 250 frames per second). Extracellular volume was quantified by cardiac magnetic resonance in 22 participants. Amyloid burden was quantified by cardiac amyloid activity in

resultsMyocardial stiffness was significantly higher in the CA cohort (median iVP, 2.6 m/s; interquartile range, 1.7-3.9 m/s) than in the hypertrophic cardiomyopathy cohort (median iVP, 1.4 m/s; interquartile range, 1.0-1.8 m/s;

conclusionsIntrinsic cardiac elastography is a reliable noninvasive tool to measure myocardial stiffness. In this pilot study, it is related to imaging markers of interstitial expansion and amyloid burden.

Indexed as

AmyloidosisCardiomyopathiesCardiomyopathy, HypertrophicElasticity Imaging TechniquesMultimodal ImagingVentricular Function, LeftAdultAgedBiomarkersCase-Control StudiesFemaleHealthy VolunteersHumansMagnetic Resonance Imaging, CineMaleMiddle AgedBiomarkersNatriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)amyloidosiscardiomyopathiescardiomyopathy, hypertrophicechocardiographyelasticity imaging techniques

Identifiers

PMID40026172
PMCPMC11919568

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.