ArticleCirculation research2025
Intestinal Microbiota Contributes to the Development of Cardiovascular Inflammation and Vasculitis in Mice.
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Article in Circulation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25citing papers in PubMed
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Who cites it
25 citing papers in PubMed.
- PasteurizedMicrobiology spectrum · 2026Article
- Akkermansia muciniphila : A next-generation gut probiotic supporting neurorepair and functional recovery.Neural regeneration research · 2026Article
- Protective role of complement signaling in Kawasaki disease vasculitis.JCI insight · 2026Article
- Metabolic Reprogramming-Driven Cardiovascular Immune Damage: From Glyco-Lipotoxicity and Epigenetic Memory to Multidimensional Cross-Organ Communication Networks.International journal of molecular sciences · 2026Review
- Recent Advances in Material Basis for Co-treatment of Cardiovascular and Gastrointestinal Disorders.Chinese journal of integrative medicine · 2026Review
- The gut microbiota and kawasaki disease: exploring the role of microbial dysbiosis and metabolites in pathogenesis and therapeutics.European journal of pediatrics · 2026Review
- Metabolic syndrome and a broken heart: trust your gut or risk your heart.American journal of physiology. Heart and circulatory physiology · 2026Review
- Multiomics approaches in Kawasaki disease: insights into pathogenesis and emerging directions for diagnosis and treatment.Clinical and experimental pediatrics · 2026Article
- Pathogenetic Gut Microbiota in Aortic Diseases: Evidence and Mechanisms Across Aneurysm, Dissection, and Inflammatory Aortopathies.Nutrients · 2026Review
- Expression of key genes in IVIG-unresponsive Kawasaki disease and their immune correlation based on bioinformatics analysis.Immunologic research · 2026Article
- Itaconate ameliorates cardiovascular inflammation in a mouse model of Kawasaki disease vasculitis - brief report.Frontiers in immunology · 2026Article
- Review
- Microbial metabolites at the nexus of gut-brain communication and neurodevelopmental disorders.Frontiers in nutrition · 2026Review
- The gut microbiota-short-chain fatty acid-inflammation axis in Parkinson's disease motor dysfunction: mechanisms and future of dietary interventions.Frontiers in neurology · 2026Review
- Recent advances in the positive role ofFrontiers in immunology · 2026Review
- Article
- The Gut-Joint Connection: Microbiome's Role in Rheumatic Disease.Archives of rheumatology · 2025Review
- Investigating the causal role of the gut microbiome in Kawasaki disease: mediating effects of immune cells.Clinical rheumatology · 2025Article
- Gut Microbiome and Immune System Crosstalk in Chronic Inflammatory Diseases: A Narrative Review of Mechanisms and Therapeutic Opportunities.Microorganisms · 2025Review
- Sirtuin 1 Activation Mitigates Murine Vasculitis Severity by Promoting Autophagy and Mitophagy.bioRxiv : the preprint server for biology · 2025Article
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Authors and funding
21 authors.
Prasant K JenaDivision of Infectious Diseases and Immunology, Department of Pediatrics, Guerin Children's at Cedars-Sinai Medical Center, Los Angeles, CA (P.K.J., D.W., A.C.G., T.T.C., A.E.A., E.A., M.N., Y.L., S.C., K.S., T.R.C., M.A., M.N.R.).ORCID 0000-0002-6729-5881
Daiko WakitaDivision of Infectious Diseases and Immunology, Department of Pediatrics, Guerin Children's at Cedars-Sinai Medical Center, Los Angeles, CA (P.K.J., D.W., A.C.G., T.T.C., A.E.A., E.A., M.N., Y.L., S.C., K.S., T.R.C., M.A., M.N.R.).
Angela C GomezDivision of Infectious Diseases and Immunology, Department of Pediatrics, Guerin Children's at Cedars-Sinai Medical Center, Los Angeles, CA (P.K.J., D.W., A.C.G., T.T.C., A.E.A., E.A., M.N., Y.L., S.C., K.S., T.R.C., M.A., M.N.R.).ORCID 0000-0001-7019-9607
Thacyana T CarvalhoDivision of Infectious Diseases and Immunology, Department of Pediatrics, Guerin Children's at Cedars-Sinai Medical Center, Los Angeles, CA (P.K.J., D.W., A.C.G., T.T.C., A.E.A., E.A., M.N., Y.L., S.C., K.S., T.R.C., M.A., M.N.R.).ORCID 0000-0002-8580-6200
Asli E AticiDivision of Infectious Diseases and Immunology, Department of Pediatrics, Guerin Children's at Cedars-Sinai Medical Center, Los Angeles, CA (P.K.J., D.W., A.C.G., T.T.C., A.E.A., E.A., M.N., Y.L., S.C., K.S., T.R.C., M.A., M.N.R.).ORCID 0000-0003-1546-7191
Emily AubuchonDivision of Infectious Diseases and Immunology, Department of Pediatrics, Guerin Children's at Cedars-Sinai Medical Center, Los Angeles, CA (P.K.J., D.W., A.C.G., T.T.C., A.E.A., E.A., M.N., Y.L., S.C., K.S., T.R.C., M.A., M.N.R.).ORCID 0009-0009-5044-5722
Meena NarayananDivision of Infectious Diseases and Immunology, Department of Pediatrics, Guerin Children's at Cedars-Sinai Medical Center, Los Angeles, CA (P.K.J., D.W., A.C.G., T.T.C., A.E.A., E.A., M.N., Y.L., S.C., K.S., T.R.C., M.A., M.N.R.).
Youngho LeeDivision of Infectious Diseases and Immunology, Department of Pediatrics, Guerin Children's at Cedars-Sinai Medical Center, Los Angeles, CA (P.K.J., D.W., A.C.G., T.T.C., A.E.A., E.A., M.N., Y.L., S.C., K.S., T.R.C., M.A., M.N.R.).ORCID 0000-0002-5227-683X
Michael C FishbeinDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA (M.C.F.).ORCID 0000-0002-6591-6306
Yoshihiro TakasatoDepartment of Allergy, Allergy and Immunology Center, Aichi Children's Health and Medical Center, Obu, Japan (Y.T.).ORCID 0000-0003-2427-3575
Yosuke KurashimaDivision of Mucosal Immunology, IMSUT Distinguished Professor Unit, The Institute of Medical Science, The University of Tokyo, Japan (Y.T., Y.K., H.K.).ORCID 0000-0001-8588-4033
Hiroshi KiyonoDivision of Mucosal Immunology, IMSUT Distinguished Professor Unit, The Institute of Medical Science, The University of Tokyo, Japan (Y.T., Y.K., H.K.).ORCID 0000-0001-7307-4658
Patrice D CaniLouvain Drug Research Institute, Metabolism and Nutrition Research Group (P.D.C.), UCLouvain, Université catholique de Louvain, Brussels, Belgium.ORCID 0000-0003-2040-2448
Willem M de VosLaboratory of Microbiology, Wageningen University, the Netherlands (W.M.d.V.).ORCID 0000-0002-0273-3166
David M UnderhillDepartment of Biomedical Sciences (D.M.U., S.D., S.C., K.S., T.R.C., M.A., M.N.R.), Cedars-Sinai Medical Center, Los Angeles, CA.ORCID 0000-0002-2989-658X
Suzanne DevkotaDepartment of Biomedical Sciences (D.M.U., S.D., S.C., K.S., T.R.C., M.A., M.N.R.), Cedars-Sinai Medical Center, Los Angeles, CA.ORCID 0000-0001-5575-9362
Shuang ChenDivision of Infectious Diseases and Immunology, Department of Pediatrics, Guerin Children's at Cedars-Sinai Medical Center, Los Angeles, CA (P.K.J., D.W., A.C.G., T.T.C., A.E.A., E.A., M.N., Y.L., S.C., K.S., T.R.C., M.A., M.N.R.).ORCID 0000-0002-2919-4967
Kenichi ShimadaDivision of Infectious Diseases and Immunology, Department of Pediatrics, Guerin Children's at Cedars-Sinai Medical Center, Los Angeles, CA (P.K.J., D.W., A.C.G., T.T.C., A.E.A., E.A., M.N., Y.L., S.C., K.S., T.R.C., M.A., M.N.R.).ORCID 0000-0001-8213-5686
Timothy R CrotherDivision of Infectious Diseases and Immunology, Department of Pediatrics, Guerin Children's at Cedars-Sinai Medical Center, Los Angeles, CA (P.K.J., D.W., A.C.G., T.T.C., A.E.A., E.A., M.N., Y.L., S.C., K.S., T.R.C., M.A., M.N.R.).ORCID 0000-0001-8465-6127
Moshe ArditiDivision of Infectious Diseases and Immunology, Department of Pediatrics, Guerin Children's at Cedars-Sinai Medical Center, Los Angeles, CA (P.K.J., D.W., A.C.G., T.T.C., A.E.A., E.A., M.N., Y.L., S.C., K.S., T.R.C., M.A., M.N.R.).ORCID 0000-0001-9042-2909
Magali Noval RivasDivision of Infectious Diseases and Immunology, Department of Pediatrics, Guerin Children's at Cedars-Sinai Medical Center, Los Angeles, CA (P.K.J., D.W., A.C.G., T.T.C., A.E.A., E.A., M.N., Y.L., S.C., K.S., T.R.C., M.A., M.N.R.).ORCID 0000-0001-5570-8928
Funding
Role of intestinal microbiome and gut permeability in the development of Kawasaki Disease vasculitisR01HL139766 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI Magali Noval Rivas · 2018 to 2026
$3.4MRole of neutrophils and eosinophils in bacterial ligand-induced vasculitisR01AI157274 · NIAID · CEDARS-SINAI MEDICAL CENTER · PI ARDITI, MOSHE, NOVAL RIVAS, MAGALI · 2020 to 2024
$3.2MRNA-Mediated Inter-Organelle Communication in AtherosclerosisR01HL149972 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI ARDITI, MOSHE · 2020 to 2023
$2.0MRole of Sex in Immune Stromal cell Interactions driving cardiovascular lesions in Kawasaki Disease vasculitisR01HL170580 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI Moshe Arditi · 2024 to 2026
$1.7MTargeting the Sirt-1 pathway to modulate inflammation during murine Kawasaki Disease vasculitisR01HL159297 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI NOVAL RIVAS, MAGALI · 2021 to 2024
$1.7MNHLBI NIH HHS R01 HL139766NHLBI NIH HHS R01 HL149972NHLBI NIH HHS R01 HL159297NHLBI NIH HHS R01 HL170580NIAID NIH HHS R01 AI157274
Abstract
backgroundAlterations in the intestinal microbiota contribute to the pathogenesis of various cardiovascular disorders, but how they affect the development of Kawasaki disease (KD) an acute pediatric vasculitis, remains unclear.
methodsWe used the
resultsWe report that depleting the gut microbiota reduces the development of cardiovascular inflammation in a murine model mimicking KD vasculitis. The development of cardiovascular lesions was associated with alterations in the intestinal microbiota composition and, notably, a decreased abundance of
conclusionsThis study reveals an underappreciated gut microbiota-cardiovascular inflammation axis in KD vasculitis pathogenesis and identifies specific intestinal commensals that regulate vasculitis in mice by producing metabolites or via extracellular proteins capable of enhancing and supporting gut barrier function.
Indexed as
Gastrointestinal MicrobiomeMucocutaneous Lymph Node SyndromeVasculitisAkkermansiaAnimalsDisease Models, AnimalInflammationLacticaseibacillus caseiMaleMiceMice, Inbred C57BLToll-Like Receptor 2Toll-Like Receptor 2coronary aneurysmcoronary vesselsgastrointestinal microbiomeinterleukin-1vasculitis
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.