ArticleJournal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG2025
High detection rate for perivascular deposits of immunoglobulins in immune complex vasculitis from biopsies of early macular lesions.
Article in Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Evidence-based guidelines for the diagnosis and management of adult-onset IgA vasculitis.Nature reviews. Rheumatology · 2026Guideline
- Fulminant Multisystem IgA Vasculitis With Diffuse Alveolar Hemorrhage, Severe Gastrointestinal Hemorrhage, Paralytic Ileus, and Renal Involvement in an Adolescent: A Case Report.Clinical case reports · 2026Article
- Idiopathic cutaneous immunoglobulin G/immunoglobulin M vasculitis is likely a distinct entity: A European multicentric retrospective study.JAAD international · 2026Article
- High detection rate for perivascular deposits of immunoglobulins in immune complex vasculitis from biopsies of early macular lesions.Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn immune complex vasculitis the detection of perivascular immunoglobulins by direct immunofluorescence (DIF) not only helps to confirm the diagnosis, but also to define the type of vasculitis (e.g., IgA-, IgG/IgM-, rheumatoid or cryoglobulinemic vasculitis). The value of DIF, though, has been questioned due to the heterogeneous yield of positive reactions in various studies. One major reason for a negative DIF is a biopsy of older lesions. To ensure selection of fresh lesions, we consistently apply morphological criteria: partially blanchable macules with only a minor petechial and papular component and in proximity to palpable or retiform purpura. This study aimed to evaluate retrospectively the detection rate attainable by this procedure. PATIENTS AND
methodsIn our department, we identified 56 patients from 2017-2024 with histologically and clinically confirmed immune complex vasculitis from whom a corresponding biopsy had been obtained.
results92.9% of these patients showed perivascular deposition of at least one immunoglobulin (mostly IgA (85,7%), with or without IgG or IgM, 7,1% showed no IgA, but IgG or IgM). Biopsies positive only for C3 were considered negative. Of the IgA-positive patients 15% had a systemic, 83% a skin-limited IgA-vasculitis and 2% recurrent macular vasculitis.
conclusionsWhen using defined morphological or clinical criteria for selecting appropriate biopsy sites, DIF demonstrates high sensitivity in identifying the nature of perivascular immunoglobulins in immune complex vasculitis and may serve as a valid criterion in diagnostic algorithms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.