ArticleJournal of Alzheimer's disease : JAD2025
Validation of the Cognitive-Emotional Perspective Taking test in patients with neurodegeneration.
Article in Journal of Alzheimer's disease : JAD, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effectiveness of transcranial electrical stimulation combined with dual-task training in stroke, mild cognitive impairment and Parkinson's disease: a systematic review and meta-analysis of randomized controlled trials.Frontiers in human neuroscience · 2025Pooled it
- Clinical patterns in social cognition & personality changes in progressive supranuclear palsy.Journal of neurology · 2026Article
- The predictive value of social cognition assessment for 1-year follow-up functional outcomes in behavioral variant frontotemporal dementia.Journal of neurology · 2025Article
- Insulin-like Growth Factor 1 Impact on Alzheimer's Disease: Role in Inflammation, Stress, and Cognition.Current issues in molecular biology · 2025Review
- Additive effect of patient anosognosia and theory of mind deficit on dementia caregiver distress.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
BackgroundTheory of mind (ToM) is crucial for socioemotional interaction. ToM deficits may explain behavioral changes in dementia, especially Alzheimer's disease (AD) and frontotemporal dementia (FTD).ObjectiveThis study examined the psychometrics of a new ToM test in healthy adults, identified ToM differences in dementia syndromes, and assessed if ToM scores predict neuropsychiatric function and real-life behavior.MethodsThe UCSF Cognitive and Emotional Perspective Taking Test (CEPT) was evaluated in 195 healthy adults (age: 42.69 ± 16.20) and in a clinic cohort of 304 participants (age: 64.07 ± 9.2). Participants included healthy controls, AD, behavioral-variant frontotemporal dementia (bvFTD), semantic variant primary progressive aphasia (svPPA), non-fluent PPA (nfvPPA), and progressive supranuclear palsy (PSP) patients. CEPT's psychometrics were assessed, and ToM differences and predictions of neuropsychiatric symptoms were analyzed using regression models.ResultsIn controls, CEPT showed good validity and reliability. In patients, CEPT scores correlated with executive and emotional measures, but not language measures, showing good construct validity. Cognitive ToM was most impaired in AD and bvFTD, with less impairment in svPPA and PSP, and all patient groups showed impaired emotional ToM. ToM performance predicted real-life neuropsychiatric behavior, including anxiety, apathy, disinhibition, and aberrant motor behaviors.ConclusionsToM deficits appear early in dementia syndromes and predict neuropsychiatric behavior. Assessing ToM and social cognition with ecologically valid tasks may help identify altered social cognition in early neurodegeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.