Evidence map›Paper›PMID 40025815›Full record

ArticleTransfusion2025

The first case of transfusion-transmitted hepatitis B virus genotype I in Japan.

Naoji Yamagishi, Naoko Ando, Takashi Yoshimasa, Shizuho Toda, Rieko Sobata, Naoko Goto, Keiji Matsubayashi, Masahiro Satake, Yoshihiko Tani

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Transfusion, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Naoji YamagishiCentral Blood Institute, Blood Service Headquarters, Japanese Red Cross Society, Tokyo, Japan.ORCID https://orcid.org/0009-0006-0007-5450
Naoko AndoCentral Blood Institute, Blood Service Headquarters, Japanese Red Cross Society, Tokyo, Japan.
Takashi YoshimasaCentral Blood Institute, Blood Service Headquarters, Japanese Red Cross Society, Tokyo, Japan.
Shizuho TodaCentral Blood Institute, Blood Service Headquarters, Japanese Red Cross Society, Tokyo, Japan.
Rieko SobataCentral Blood Institute, Blood Service Headquarters, Japanese Red Cross Society, Tokyo, Japan.
Naoko GotoBlood Service Headquarters, Japanese Red Cross Society, Tokyo, Japan.
Keiji MatsubayashiCentral Blood Institute, Blood Service Headquarters, Japanese Red Cross Society, Tokyo, Japan.
Masahiro SatakeBlood Service Headquarters, Japanese Red Cross Society, Tokyo, Japan.ORCID https://orcid.org/0000-0002-4660-6839
Yoshihiko TaniCentral Blood Institute, Blood Service Headquarters, Japanese Red Cross Society, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn Japan, the risk of transfusion-transmitted hepatitis B virus (TT-HBV) infection has been reduced since 2014 by implementing individual donation nucleic acid amplification testing (ID-NAT). CASE REPORT: A male repeat blood donor in his 20s converted positive for HBV DNA and hepatitis B surface antigen. Red cell concentrate from his previous donation had been transfused into a woman in her 70s. Her serum showed HBV DNA positivity 62 days after transfusion. HBV genome sequences across two regions were shown to be identical in the donor and recipient. The HBV full-length genome sequence from the donor belonged to nonindigenous subgenotype I1. It contained double mutations A1762T and G1764A, which are associated with hepatocellular carcinoma development. The donor had no history of traveling abroad within 126 days prior to the index donation, so he was probably infected with HBV in Japan. DISCUSSION: Including this case, nine cases of TT-HBV from eight blood donations have been detected in Japan since the introduction of ID-NAT. Seven of the eight TT-HBV-related donations had HBV subgenotypes that were exotic to Japan. Exotic HBV strains spreading in Japan pose a risk of TT-HBV owing to ongoing acute HBV infection with these strains.

Indexed as

Blood DonorsHepatitis BHepatitis B virusTransfusion ReactionAgedDNA, ViralFemaleGenotypeHumansJapanMaleDNA, Viralhepatitistransfusiontransmitted disease

Identifiers

PMID40025815
PMCPMC12005574

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.