ArticleJournal of biochemical and molecular toxicology2025
Myrtenal Pretreatment Exerts a Protective Effect Against Renal Ischemia-Reperfusion Injury in Rats.
Article in Journal of biochemical and molecular toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Plant metabolites: potential treatments for ischemic acute kidney injury.Frontiers in pharmacology · 2026Review
- Renoprotective mechanisms of bioconverted wild-simulated ginseng: mitigating oxidative stress, inflammation, and apoptosis to protect against ischemic renal injury via Nrf2/HO-1/NF-κB/caspase-3 signaling.Journal of ginseng research · 2026Article
- Myrtenal Ameliorates Ischemic Brain Injury Diabetic and Non-Diabetic Rats.Neurochemical research · 2025Article
- Asprosin protects against ischemia/reperfusion-induced kidney injury in mice.Journal of molecular histology · 2025Article
- Involvement of hypoxia-inducible factor1-alpha in the protective effect of rivaroxaban against testicular ischemia-reperfusion in rats.Scientific reports · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Acute kidney injury (AKI) is a serious condition with high mortality in intensive care units and during vascular surgeries. Renal ischemia-reperfusion injury (IRI) significantly contributes to AKI. Preclinical studies have shown that myrtenal (Myrt) has anti-inflammatory and antioxidant properties. We hypothesized that Myrt might alleviate renal damage caused by IRI through the modulation of oxidative stress and inflammatory processes. This study aimed to investigate the renoprotective potential of Myrt against IRI using biochemical evaluations and histological examinations. Forty male Sprague Dawley rats were assigned to four groups: sham, IRI, Myrt40+IRI, and Myrt80+IRI. Animals received daily intraperitoneal injections of Myrt (40-80 mg/kg) or solvent for 9 days before surgery. The sham group underwent laparotomy, while the other groups had AKI induced via bilateral renal pedicle clamping for 45 min, followed by 24 h of reperfusion. Renal function was assessed by blood urea nitrogen (BUN), creatinine, kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) levels. Inflammatory markers interleukin-1 beta (IL-1β), tumor necrosis factor-alpha (TNF-α) were measured, along with oxidative stress parameters malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH). Renal damage was evaluated histopathologically using hematoxylin and eosin staining and apoptosis was assessed via caspase-3 immunohistochemistry. In the IRI group, serum BUN and creatinine levels were significantly higher than the sham group but were reduced by Myrt pretreatment (p < 0.05). IRI also led to significant increases in MDA, KIM-1, NGAL, IL-1β, and TNF-α in kidney tissue (p < 0.05), which were notably decreased by Myrt pretreatment (p < 0.05). Myrt also restored SOD and CAT enzyme activities and GSH levels reduced by IRI (p < 0.05). Histological analysis showed Myrt significantly alleviated renal tissue damage and reduced caspase-3 immunoreactivity due to IRI (p < 0.05). The findings suggest that Myrt has a protective effect against renal IRI.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.