Evidence map›Paper›PMID 40025620›Full record

ArticleArthritis research & therapy2025

Unraveling the role of lncRNAs and their associated nearby coding genes in the pathogenesis of systemic lupus erythematosus.

Tao Liu, Mingyue Yang, Xiunan Feng, Xiaojuan Zou, Ying Xia, Lu Chen, Zixin Gao, Ling Zhao, Xiaosong Wang

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In one paragraph

Article in Arthritis research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Tao LiuDepartment of Rheumatology and Immunology, The First Hospital of Jilin University, Changchun, 130021, China.
Mingyue YangDepartment of Translational Medicine, The First Hospital of Jilin University, Changchun, 130021, China.
Xiunan FengDepartment of Rheumatology and Immunology, The First Hospital of Jilin University, Changchun, 130021, China.
Xiaojuan ZouDepartment of Rheumatology and Immunology, The First Hospital of Jilin University, Changchun, 130021, China.
Ying XiaDepartment of Translational Medicine, The First Hospital of Jilin University, Changchun, 130021, China.
Lu ChenDepartment of Rheumatology and Immunology, The First Hospital of Jilin University, Changchun, 130021, China.
Zixin GaoDepartment of Rheumatology and Immunology, The First Hospital of Jilin University, Changchun, 130021, China.
Ling ZhaoDepartment of Rheumatology and Immunology, The First Hospital of Jilin University, Changchun, 130021, China. zhaoling17@jlu.edu.cn.
Xiaosong WangDepartment of Translational Medicine, The First Hospital of Jilin University, Changchun, 130021, China. xiaosongwang@jlu.edu.cn.

Funding

Department of Science and Technology of Jilin Province 20210204174YYFirst Hospital of Jilin University 04032690001First Hospital of Jilin University JDYY14202322Jilin University "The Bethune Grant" 2023B07Science and Technology Department of Jilin Province YDZJ202201ZYTS018
6 · The paper itself

Abstract

backgroundThe role of long non-coding RNAs (lncRNAs) and their nearby messenger RNAs (mRNAs) in systemic lupus erythematosus (SLE) pathogenesis is not well understood.

methodHigh-throughput sequencing was utilized to analyze PBMCs obtained from SLE patients. Subsequently, we conducted differential analysis, Gene Ontology (GO) analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, and verification through quantitative real-time PCR (qRT-PCR). Additionally, qRT-PCR was used to analyze the levels of lncRNAs or mRNAs in transfected Raji cells.

resultsWe identified 419 differentially expressed (DE) lncRNAs and their 337 nearby DE mRNAs in SLE patients. More than 67% of the DE lncRNAs were lincRNAs and intronic_lncRNAs. The most significantly regulated nearby mRNAs in SLE patients were LTF and CIRBP, potentially involved in recurrent infection and photosensitivity. GO analysis revealed upregulation of the immune effector process term, with genes such as C1qA, C1qC, C1qB, NLRP3, and CXCL6 participating in this term and the upregulated pertussis signaling pathway. Analysis of the nearby coding genes of 88 lincRNAs indicated that XLOC_185773 had the highest number of nearby encoding genes and was negatively correlated with peripheral blood lymphocyte counts, potentially regulating HARS. Furthermore, LNC_005556, an antisense DE lncRNA, was negatively correlated with lupus nephritis occurrence and may regulate the upregulated IGLL5 in patients.

conclusionsThe current study provides insights into the dysregulation of lncRNAs and nearby mRNAs in SLE, highlighting potential key players in the pathogenesis of the disease.

Indexed as

Lupus Erythematosus, SystemicRNA, Long NoncodingRNA, MessengerAdultFemaleGene Expression ProfilingGene Expression RegulationHigh-Throughput Nucleotide SequencingHumansMaleRNA, Long NoncodingRNA, MessengerHigh-throughput sequencingLong non-coding RNANearby coding genesPeripheral blood mononuclear cellsSystemic lupus erythematosus

Identifiers

PMID40025620
PMCPMC11871770

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