Evidence map›Paper›PMID 40025615›Full record

ArticleNeurological research and practice2025

Chronic Candida albicans meningoencephalitis in a patient with mantle cell lymphoma: a diagnostic challenge.

Johannes L Busch, Justus Schikora, Lisa-Marie Wackernagel, Jawed Nawabi, Matthias Endres, Klemens Ruprecht

Abstract readLetter
In one paragraph

Article in Neurological research and practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Johannes L Busch *Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0002-1280-5928
Justus Schikora *Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Lisa-Marie WackernagelDepartment of Infectious Diseases, Respiratory Medicine Berlin and Intensive Care, Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0003-0596-0724
Jawed NawabiInstitute for Neuroradiology, Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0002-1137-0643
Matthias EndresDepartment of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0001-6520-3720
Klemens RuprechtDepartment of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany. klemens.ruprecht@charite.de.ORCID http://orcid.org/0000-0003-1962-6014

Funding

Berlin Institute of Health Junior Clinician Scientist Program
6 · The paper itself

Abstract

Due to its unspecific clinical presentation and the multitude of possible etiologies, chronic meningoencephalitis in immunosuppressed patients often represents a diagnostic challenge. Here, we report the clinical, radiological, cerebrospinal fluid, and microbiological findings of a 54-year-old male immunocompromised patient with mantle cell lymphoma and a 2-month history of brainstem and spinal meningoencephalitis. After unsuccessful treatment trials with antibiotics, a Candida albicans infection was confirmed by biopsy of a spinal cord lesion and large-volume cerebrospinal fluid culture. Therapy with liposomal amphotericin B/flucytosine and subsequent fluconazole resulted in significant clinical improvement. This case illustrates the importance of identifying the underlying cause of chronic meningoencephalitides in immunocompromised patients.

Indexed as

Candida albicansCerebrospinal fluidEncephalitisMeningitisMeningoencephalitisNeurocandidiasis

Identifiers

PMID40025615
PMCPMC11921972

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.