ArticleBMC chemistry2025
A green three-ratio manipulating spectrophotometric approaches for the determination of a binary mixture of pantoprazole and domperidone.
Article in BMC chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Green ratio-manipulating spectrophotometric methods for simultaneous determination of empagliflozin and sitagliptin in pharmaceutical formulations.BMC chemistry · 2026Article
- Unveiling advanced green assessment of simple and cost effective spectrophotometric determination of domperidone and pantoprazole for gastrointestinal disorders.Scientific reports · 2026Article
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4 authors.
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Abstract
backgroundPantoprazole (PAN) is a proton pump inhibitor used to treat GERD and hyperacidity by suppressing gastric acid secretion, effectively relieving symptoms such as heartburn, acid regurgitation, and indigestion. Domperidone (DOM) is a prokinetic agent that enhances gastrointestinal motility, helping to alleviate nausea, vomiting, and bloating caused by motility disorders. Their combination (Pantosec-D) provides rapid and comprehensive relief from both acid-related and motility-related symptoms, significantly improving patient comfort and quality of life.
objectiveThis study aims to develop and validate three eco-friendly spectrophotometric techniques-ratio difference (RD), first derivative (1DD), and mean centering (MC) of ratio spectra-for the simultaneous determination of PAN and DOM in pharmaceutical formulations.
methodThe proposed methods resolve spectral overlap through ratio spectra manipulation. In the RD method, DOM is quantified by measuring the amplitude difference at 209 nm and 233 nm, while PAN is determined at 254 nm and 223 nm. The
resultsThe suggested methods were validated according to ICH regulations. Pharmaceutical formulations comprising PAN and DOM were effectively analyzed using the linear correlations obtained for both drugs over concentration ranges of 0.5-52 µg/mL and 1-18 µg/mL, respectively.
conclusionCompared with reported spectrophotometric techniques, ratio methods are especially beneficial for routine pharmaceutical analysis due to their ease of use, capacity for handling overlapping spectra, and robustness to experimental variations. Compared with reported chromatographic methods, these techniques provide easy-to-use, reasonably priced, less solvent, and dependable substitutes for the standard quality control of these medications in pharmaceutical dosage forms.
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