Observational studyItalian journal of pediatrics2025
Evaluation of uNGAL and TIMP-2*IGFBP7 as early biomarkers of Acute Kidney Injury in Caucasian term and preterm neonates: a prospective observational cohort study.
Observational study in Italian journal of pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
4 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Novel biomarkers for acute kidney injury in high-risk pediatric populations: a systematic review.Renal failure · 2026Pooled it
- Optimizing pediatric AKI diagnosis: a patient-tailored meta-analysis of urinary TIMP-2/IGFBP7 performance across clinical scenarios and assay platforms.Frontiers in pediatrics · 2025Pooled it
- A Pathophysiological Approach for Early Detection and Prevention of AKI in the NICU.American journal of perinatology · 2026Review
- Urinary KIM-1 for Early Detection of Acute Kidney Injury in Neonates: A Systematic Review and Meta-Analysis.Life (Basel, Switzerland) · 2025Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundEarly diagnosis of Acute Kidney Injury (AKI) in neonates is a complex challenge. Novel urinary biomarkers such as uNGAL and TIMP-2*IGFBP7 may be helpful for predicting AKI earlier than changes in serum creatinine (sCr) and urinary output (UOP) in the neonatal period. uNGAL is a marker of tubular injury and its concentration rises immediately after AKI, while the proteins TIMP-2 and IGFBP7 jointly participate in the G1 phase cell cycle arrest processes and their tubular expression and urinary excretion increase in response to kidney damage. The aim of this study is to determine urinary concentrations of uNGAL and TIMP-2*IGFBP7 in term and preterm newborns and to evaluate their predictive role of AKI.
methodsForty-two heathy term neonates and twenty-six preterm infants were prospectively recruited at the NICU of Policlinico in Bari, Italy. uNGAL and TIMP-2*IGFBP7 were measured in fresh urinary samples collected via perineal bag either before discharge (term neonates) or over the first week of life (preterm neonates).
resultsIn term neonates median uNGAL and TIMP-2*IGFBP7 concentrations were 41.40 ng/ml (IQR 20.25-74.5) e 0.22 (ng/ml)
conclusionsOur data show that uNGAL could be more useful than TIMP-2*IGFBP7 for early detection of AKI in preterm newborns. Further studies are needed to evaluate the role of both biomarkers during AKI and their relationship with gender, gestational age and birth weight.
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