ArticleBMC veterinary research2025
Sodium butyrate alleviates high ambient temperature-induced oxidative stress, intestinal structural disruption, and barrier integrity for growth and production in growing layer chickens.
Article in BMC veterinary research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Intestinal health of broiler chickens fed red seaweed (Chondracanthus chamissoi) under dexamethasone-induced stress.Poultry science · 2026Article
- Dietary betaine alleviates corticosterone-induced intestinal barrier dysfunction in laying hens possibly by promoting tight junction protein expression via mPoultry science · 2026Article
- Total saponins of Gynostemma pentaphyllum mitigate chronic heat stress-induced thymus and spleen inflammation in broilers via NF-κB pathway activation.Poultry science · 2026Article
- Dietary dimethylglycine sodium salt improves growth performance, liver function, and meat quality of broilers exposed to heat stress.Poultry science · 2026Article
- Effects of Simulated Typhoon Stress on Ovarian Function in Wenchang Chickens: An Exploration Based on the Microbiota-Gut-Brain-Ovarian Axis.Animals : an open access journal from MDPI · 2026Article
- Differential impact of sodium butyrate forms on intestinal morphology, gene expression, and growth performance in broiler chickens under cold stress at high altitude.Veterinary and animal science · 2026Article
- Effects of Sodium Butyrate Forms on Carcass Performance, Pulmonary Hypertension, Metabolic Health and Oxidative-Inflammatory Responses in Broiler Chickens Under Cold Stress at High Altitude.Veterinary medicine and science · 2026Article
- Sodium Butyrate Promotes In Vitro Development of Mouse Preantral Follicles and Improves Oocyte Quality by Regulating Steroidogenesis, Oxidative Stress, and Cytoskeleton Remodeling.Animals : an open access journal from MDPI · 2025Article
- Butyric, lactic, and propionic acids with their salts as natural growth promoters in broilers.Scientific reports · 2025Article
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12 authors.
Funding
Abstract
backgroundThis study was conducted to evaluate the effects of dietary sodium butyrate (SB) supplementation on the antioxidant status, intestinal morphology, functional damage, and barrier integrity of heat-stressed Hy-Line Sonia (HYS) layer chicks. A total of 240 female HYS at 35 days of age with average body weights (415 ± 35 g) were divided into 6 groups with 10 replicates/group and 4 chickens per replicate. A 2 × 3 factorial design study was performed, including two conditions of ambient temperature (25 °C and 35 °C) and three dietary levels of SB (0, 0.5, and 1.0 SB g/kg diet).
resultsHS decreased (P < 0.05) the performance parameters final body weight (FBW), average daily gain (ADG), and average daily feed intake (ADFI), and increased mortality; compared with the HS groups, supplementation with SB decreased mortality. Compared with thermoneutral conditions, the high-temperature conditions significantly decreased (P < 0.05) the thymus, liver, and heart weights, and the relative length of the jejunum, ileum, and cecum, whereas supplementation with 0.5 SB g/kg diet increased (P < 0.05) the weight of the spleen in growing layer chickens. High temperature decreased (P < 0.05) the villus height (VH) and VH/CD ratio, and increased the crypt depth (CD), and supplementation with SB and the T × SB interaction produced greater VH and VH/CD values in the LSB2 and HSB2 groups. SB decreased (P < 0.05) the concentration of serum malondialdehyde (MDA); however, high temperature decreased (P < 0.05) the activities of the catalase (CAT) and glutathione peroxidase (GSH-Px) antioxidant enzymes. The relative mRNA expression levels of the occluding, zonula occludens-1 (ZO-1), claudin-1, and interleukin-10 (IL-10) proteins were downregulated (P < 0.05) at high-temperatures, while that of transforming growth factor-β (TGFβ) was upregulated. Dietary supplementation decreased the expression of the inflammatory cytokines nuclear factor kappa B (NF-κB), transforming growth factor-β (TGFβ), and interferon-γ (IFNγ), and the T × SB interaction decreased TGFβ gene expression in the LSB2 and HSB2 groups compared with that in the other groups of growing layer chickens.
conclusionSB supplementation effectively alleviated HS-induced oxidative stress and structural and functional damage to the intestine in layer chickens in the growing phase.
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