Evidence map›Paper›PMID 40025537›Full record

ReviewJournal of nanobiotechnology2025

Nanomedicine's shining armor: understanding and leveraging the metal-phenolic networks.

Zhengming Tang, Zhijie Huang, Yisheng Huang, Mingshu Huang, Hongyu Liu, JianZhong Du, Bo Jia

Abstract readReview
In one paragraph

Review in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

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  5. FeiScience · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhengming TangStomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, China.ORCID http://orcid.org/0000-0001-8034-1443
Zhijie HuangStomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, China.
Yisheng HuangYuexiu District Stomatological Hospital, Guangzhou, Guangdong, China.
Mingshu HuangStomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, China.
Hongyu LiuStomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, China.
JianZhong Du *Department of Gynaecology and Obstetrics, Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, School of Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital, Tongji University, Shanghai, 200434, China. jzdu@tongji.edu.cn.ORCID http://orcid.org/0000-0003-1889-5669
Bo Jia *Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, China. dentist-jia@163.com.ORCID http://orcid.org/0000-0002-7178-424X

Funding

Guangdong Provincial Administration of Traditional Chinese Medicine Scientific Research General Project 20251265Guangdong Provincial Key Areas Special Project for General Universities 2023ZDZX2009Guangdong Provincial Medical Science and Technology Research Fund Project B2023413the program of Stomatological Hospital, School of Stomatology, Southern Medical University ( PY2022015
6 · The paper itself

Abstract

Metal-phenolic networks (MPNs), which comprise supramolecular amorphous networks formed by interlinking polyphenols with metal ions, garner escalating interest within the realm of nanomedicine. Presently, a comprehensive synthesis of the cumulative research advancements and utilizations of MPNs in nanomedicine remains absent. Thus, this review endeavors to firstly delineate the characteristic polyphenols, metal ions, and their intricate interaction modalities within MPNs. Subsequently, it elucidates the merits and demerits of diverse synthesis methodologies employed for MPNs, alongside exploring their potential functional attributes. Furthermore, it consolidates the diverse applications of MPNs across various nanomedical domains encompassing tumor therapy, antimicrobial interventions, medical imaging, among others. Moreover, a meticulous exposition of the journey of MPNs from their ingress into the human body to eventual excretion is provided. Lastly, the persistent challenges and promising avenues pertaining to MPNs are delineated. Hence, this review offering a comprehensive exposition on the current advancements of MPNs in nanomedicine, consequently offering indirect insights into their potential clinical implementation.

Indexed as

MetalsNanomedicinePhenolsPolyphenolsAnimalsHumansNeoplasmsMetalsPhenolsPolyphenolsMetal-polyphenol networksNanomedicinePolyphenol-containing structuresPolyphenols

Identifiers

PMID40025537
PMCPMC11874145

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.