Observational studyBMC pediatrics2025
Diazepam exposure associated with an increased risk of acute kidney injury in children: an observational cohort study.
Observational study in BMC pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- A Low Matrix Effects Analytical Strategy for Diazepam Analysis in Aquatic Products Through Immunomagnetic Beads Purification.Foods (Basel, Switzerland) · 2026Article
- Gallic Acid-Mediated Enhancement of Diazepam-Induced Sedation via GABAFood science & nutrition · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundPotentially nephrotoxic drugs play an important role in acute kidney injury (AKI) in children. In the previous pharmacovigilance study, we found a statistical correlation between diazepam and AKI in children, but the causality needs to be further verified.
methodsAn observational cohort study was conducted to investigate the association between diazepam exposure and the risk of AKI in hospitalized children. The exposed group received diazepam while the control group did not. The outcome was AKI in accordance with the Kidney Disease Improving Global Outcomes (KDIGO) guidelines. Logistic regression was used to explore the association between diazepam exposure and the risk of AKI in children after adjusting for covariates.
resultsA total of 3018 hospitalized children were included, 148 in the diazepam group and 2870 in the control group. After adjusting for covariates, diazepam exposure was associated with an increased risk of AKI in children (OR = 1.85, 95%CI: 1.11-3.09, P = 0.019). Multivariate logistic regression showed that age (P < 0.001), low baseline serum creatinine (P < 0.001), chronic kidney disease (P = 0.039), diuretics (P = 0.009), Non-steroidal anti-inflammatory drugs (NSAIDs, P = 0.046), proton pump inhibitors (P = 0.007) and vasoactive drugs (P = 0.007) were risk factors for diazepam-associated AKI in children.
conclusionsThe use of diazepam in children is associated with an increased risk of AKI. The risk factors for diazepam-associated AKI in children included age, low baseline serum creatinine, chronic kidney disease, diuretics, NSAIDs, proton pump inhibitors, and vasoactive drugs.
trial registrationChiCTR2400085281 2024-06-04 (retrospectively registered).
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