ReviewAnnals of surgical oncology2025
The Landmark Series: Advances in Preoperative Mediastinal Lymph Node Staging for Non-small Cell Lung Cancer (NSCLC).
Review in Annals of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diagnostic accuracy of CT-based radiomics for predicting occult lymph node metastasis in early-stage lung adenocarcinoma: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Minimally Invasive Sampling Techniques for Pancreatic and Pulmonary Nodules: A Review of the Evolution of Guidance and Sampling Methods.Diagnostic cytopathology · 2026Review
- The extent of lymph node dissection in early-stage non-small cell lung cancer: current controversies, evidence gaps, and future directions in the immunotherapy era-a narrative review.Journal of thoracic disease · 2026Review
- Efficacy without compromising resection: surgical outcomes from AEGEAN.Journal of thoracic disease · 2026Article
- Comparison of Mediastinal Metastases of Primary Lung Cancer Versus Extrathoracic Malignancies in Patients Obtained with Endobronchial Ultrasonography-Guided Transbronchial Needle Aspiration Biopsy: A Single-Center Retrospective Study.Medicina (Kaunas, Lithuania) · 2026Article
- Neoadjuvant chemoimmunotherapy in non-small cell lung cancer: evolving resectability criteria, biomarker-driven postoperative management, and emerging therapeutic strategies.Journal for immunotherapy of cancer · 2026Review
- Construction and validation of a predictive model for benefits of tunnel-type mediastinal lymph node dissection in lung cancer patients based on the SEER database.BMC medical informatics and decision making · 2026Article
- Optimizing Lymph Node Staging in Non-Small Cell Lung Cancer Surgery: Evidence, Guidelines, and Quality Improvement Strategies.Journal of clinical medicine · 2026Review
- HOXA9 drives lymphatic metastasis by activating the c-MYC-glycolysis-lactate axis in gastric cancer.Journal of translational medicine · 2025Article
- Multi-Level Oncological Management of a Rare, Combined Mediastinal Tumor: A Case Report.Current oncology (Toronto, Ont.) · 2025Article
- The clinical utility of endobronchial ultrasound-guided transbronchial needle aspiration: A single-center experience from the Middle East.Annals of thoracic medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Accurate mediastinal staging is essential for determining the extent of lung cancer, predicting prognosis, and guiding treatment strategies. Current clinical guidelines recommend preoperative invasive mediastinal staging for most patients with potentially resectable lung cancer, as imaging modalities alone often lack sensitivity and specificity. Invasive mediastinal staging techniques are categorized into surgical (e.g., cervical mediastinoscopy, video-assisted thoracic surgery) and nonsurgical (i.e., minimally invasive) approaches. Although cervical mediastinoscopy has historically been the gold standard, minimally invasive techniques have gained prominence in recent decades. These approaches, including endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA), endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA), and combined EBUS/EUS, provide improved accuracy and reduced morbidity compared with traditional surgical methods. EBUS-TBNA facilitates access to a broad range of lymph node stations with real-time ultrasound guidance, while EUS-FNA complements EBUS by enabling transesophageal lymph node sampling. Together, these techniques enable a more comprehensive mediastinal staging. This review examines five key trials that explore the expanding role of endobronchial and endoscopic techniques in mediastinal staging for non-small cell lung cancer, demonstrating how these advancements have transformed the diagnostic landscape.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.