Evidence map›Paper›PMID 40025353›Full record

ArticleJournal of natural medicines2025

Grandifolins A-D: three 6/6/5 abietane diterpenes and an abietane diterpene from Salvia grandifolia.

Hiroshi Kawabe, Teppei Komiyama, Yoshinori Saito, Yasuko Okamoto, Emi Hara, Keiichi Matsuzaki, Motoo Tori, Ryo Hanai, Hiroshi Hirota, Xun Gong and 3 more

Abstract read
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Article in Journal of natural medicines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Hiroshi KawabeCollege of Humanities and Sciences, Nihon University, Setagaya-ku, Tokyo, 156-8550, Japan.
Teppei KomiyamaLaboratory for Biomaterials and Bioengineering, Institute of Integrated Research, Institute of Science Tokyo, Chiyoda-ku, Tokyo, 101-0062, Japan.
Yoshinori SaitoGraduate School of Biomedical Sciences, Nagasaki University, Bunkyo-machi, Nagasaki, 852-8521, Japan.
Yasuko OkamotoFaculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima, 770-8514, Japan.
Emi HaraCollege of Humanities and Sciences, Nihon University, Setagaya-ku, Tokyo, 156-8550, Japan.
Keiichi MatsuzakiSchool of Pharmacy, Nihon University, Narashinodai, Funabashi, Chiba, 274-8885, Japan.
Motoo ToriFaculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima, 770-8514, Japan.
Ryo HanaiCollege of Science, Rikkyo University, Nishi-Ikebukuro, Toshima-ku, Tokyo, 171-8501, Japan.
Hiroshi HirotaCollege of Humanities and Sciences, Nihon University, Setagaya-ku, Tokyo, 156-8550, Japan.
Xun GongKunming Institute of Botany, Chinese Academy of Science, Kunming, 650204, China.
Chiaki KurodaCollege of Science, Rikkyo University, Nishi-Ikebukuro, Toshima-ku, Tokyo, 171-8501, Japan.
Hiroyuki KagechikaLaboratory for Biomaterials and Bioengineering, Institute of Integrated Research, Institute of Science Tokyo, Chiyoda-ku, Tokyo, 101-0062, Japan.
Ayumi OhsakiCollege of Humanities and Sciences, Nihon University, Setagaya-ku, Tokyo, 156-8550, Japan. ohsaki.ayumi@nihon-u.ac.jp.

Funding

Grant-in-Aid for Scientific Research from JSPS 16K01921Grant-in-Aid for Scientific Research from JSPS 20K05736Grant-in-Aid for Scientific Research from JSPS 24510293Grant-in-Aid for Scientific Research from JSPS 25303010
6 · The paper itself

Abstract

The genus Salvia is a well-established source of biologically active compounds with beneficial health effects. In this study, we aimed to isolate and structurally characterize novel compounds from Salvia grandifolia and evaluate their cytotoxic activity against human promyelocytic leukemia (HL-60) and cervical cancer (HeLa) cell lines. Three new rearranged abietane-type diterpenes, grandifolins A-C (1-3) and a new abietane diterpene, grandifolin D (4), were isolated from the roots of Salvia grandifolia, along with 12 known compounds (5-16). Their structures were determined by combining extensive

Indexed as

AbietanesAntineoplastic Agents, PhytogenicSalviaCrystallography, X-RayHeLa CellsHL-60 CellsHumansMolecular StructurePlant RootsAbietanesAntineoplastic Agents, Phytogenic6/6/5 skeletonCytotoxicityDiterpenoidLamiaceaeRearranged abietaneSalvia grandifolia

Identifiers

PMID40025353

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.