Evidence map›Paper›PMID 40025271›Full record

ArticleAnalytical sciences : the international journal of the Japan Society for Analytical Chemistry2025

Stratified quantification of targets in skin by three-dimensional Raman spectroscopic imaging.

Yunchi Hu, Tong Ha, Yan Kang, Yiping Du

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Article in Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yunchi HuSchool of Chemistry & Molecular Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, People's Republic of China.
Tong HaSchool of Chemistry & Molecular Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, People's Republic of China.
Yan KangSchool of Chemistry & Molecular Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, People's Republic of China. kangyanhd@ecust.edu.cn.ORCID http://orcid.org/0009-0000-9819-1068
Yiping DuSchool of Chemistry & Molecular Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aims to utilize three-dimensional (3D) Raman imaging technology for the stratified quantification of active ingredients (AIs) within the skin, which involves determining their contents in the stratum corneum (SC) and the active epidermal (EP) layer. Multiple linear regression combined with a least squares algorithm was used to analyze the relative concentration coefficients of targets in the skin. However, an issue of signal attenuation with increasing depth was encountered during the 3D Raman data acquisition process. A calibration process was performed based on establishing the relationships among depth in skin, the relative concentration coefficients of a two-dimensional (2D) Raman imaging and the concentration value from high-performance liquid chromatography (HPLC) technology. Nicotinamide was selected as the target in this study, and a 3D Raman signal attenuation correction equation specific to nicotinamide was developed. A 3D stratified imaging of nicotinamide in skin was achieved by this method. This method offers a visual analysis of AIs in the SC and EP by in vivo Raman technology.

Indexed as

Imaging, Three-DimensionalNiacinamideSkinSpectrum Analysis, RamanCalibrationHumansNiacinamideHigh-performance liquid chromatographyNicotinamideStratified quantitative analysis of the skinThree-dimensional Raman imagingTwo-dimensional Raman imaging

Identifiers

PMID40025271

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.