ArticleScientific reports2025
Therapeutic effect of pH responsive Magainin II modified azithromycin plus curcumin micelles in different depth models of MRSA infection.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Potential of Antimicrobial Peptide Synergies for Combating Infectious Diseases in Aquaculture: A Review.Animals : an open access journal from MDPI · 2026Review
- Expanding the Antimicrobial Toolbox with Therapeutic Viruses: Mechanisms, Pharmaceutical Formulation, and Translational Outlook.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Antimicrobial Peptides in Preventive Medicine: Current Perspectives on Coating Strategies.ACS infectious diseases · 2026Review
- Rapid neuralized and vascularized osteogenesis in infected bone defect using biomimetic biomineralized and antibacterial hydrogels.Frontiers in bioengineering and biotechnology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
Methicillin-resistant Staphylococcus aureus (MRSA) is a major pathogen responsible for serious infections in humans. The overuse of antibiotics has led to the evolution of resistance genes in bacteria. This study aimed to develop a pH-responsive micelle, loaded with therapy drugs and modified with antimicrobial peptides, to treat drug-resistant bacterial infections at varying depths. pH-responsive micelles containing azithromycin and curcumin, modified with Magainin II, were prepared using the thin-film dispersion method. The physicochemical properties of the micelles were characterized, and their targeting properties and therapeutic effects on bacterial infections were investigated both in vivo and in vitro across various depths. The micelles demonstrated excellent targeting of bacterial infection sites and released drugs in response to degradation at the disease site. The combination of curcumin and azithromycin effectively mitigated bacterial resistance through multiple mechanisms, enhancing the antibacterial effect while reducing the required azithromycin dosage and associated toxicity. In infection models of varying depths-skin, muscle, and lungs-the micelles exhibited strong antibacterial, anti-biofilm, and anti-inflammatory effects with low toxicity. These findings provide a promising strategy for addressing drug-resistant bacterial infections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.