Trial reportScientific reports2025
Autonomic correlates of osteopathic manipulative treatment on facial functional mapping: an innovative approach based on thermal imaging.
Trial report in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
- Erratum issued
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteopathic manipulative treatment (OMT) has shown efficacy in various clinical conditions and age groups. Understanding its neurobiological, particularly autonomic, mechanisms of action remain limited. Preliminary studies suggested a parasympathetic effect of OMT, evidenced by heart-rate-variability analysis. A cross-over RCT on healthy adults was conducted to compare OMT with sham therapy. Thirty-seven participants underwent two sessions (OMT and sham), comprising baseline, tactile treatment, and post-touch. Novel thermal imaging data analyses in combination with seed correlation analyses (SCA) were employed to explore the OMT effects on autonomic parameters. Particularly, the sham group exhibited an elevated warming effect on the cheeks, nose, and chin. Inversely, for the OMT group a conspicuous cooling trend in the nose, but not in the cheeks and chin was observed. Considering SCA maps, the intensity of the correlation for nose tip, glabella and GSR seeds showed higher values in the OMT compared to the sham group. The comparative analysis of thermal maps and SCA results represents a significant advancement in our understanding of the physiological mechanisms underlying OMT's effects on autonomic functions. By elucidating specific patterns of temperature change, correlation intensity and specific clusters, this research provides valuable insights for optimizing clinical practice and refining theoretical models of manual therapy.
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