Evidence map›Paper›PMID 40025196›Full record

ArticleCellular and molecular life sciences : CMLS2025

Cell-type-specific requirement for TYK2 in murine immune cells under steady state and challenged conditions.

Anzhelika Karjalainen, Agnieszka Witalisz-Siepracka, Michaela Prchal-Murphy, David Martin, Felix Sternberg, Milica Krunic, Marlies Dolezal, Nikolaus Fortelny, Matthias Farlik, Sabine Macho-Maschler and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Anzhelika KarjalainenAnimal Breeding and Genetics, Department of Biological Sciences and Pathobiology, University of Veterinary Medicine Vienna, Vienna, Austria.
Agnieszka Witalisz-SieprackaAnimal Breeding and Genetics, Department of Biological Sciences and Pathobiology, University of Veterinary Medicine Vienna, Vienna, Austria.
Michaela Prchal-MurphyPharmacology and Toxicology, Department of Biological Sciences and Pathobiology, University of Veterinary Medicine Vienna, Vienna, Austria.
David MartinAnimal Breeding and Genetics, Department of Biological Sciences and Pathobiology, University of Veterinary Medicine Vienna, Vienna, Austria.
Felix SternbergPhysiology and Biophysics, Department of Biological Sciences and Pathobiology, University of Veterinary Medicine Vienna, Vienna, Austria.
Milica KrunicCampus Tulln, University of Applied Sciences Wiener Neustadt, Wiener Neustadt, Austria.
Marlies DolezalPlatform Biostatistics and Bioinformatics, Department of Biological Sciences and Pathobiology, University of Veterinary Medicine Vienna, Vienna, Austria.
Nikolaus FortelnyDepartment of Biosciences and Medical Biology, Center for Tumor Biology and Immunology, Paris-Lodron University Salzburg, Salzburg, Austria.
Matthias FarlikDepartment of Dermatology, Medical University of Vienna, Vienna, Austria.
Sabine Macho-MaschlerAnimal Breeding and Genetics, Department of Biological Sciences and Pathobiology, University of Veterinary Medicine Vienna, Vienna, Austria.
Caroline LassnigCore Facility VetBiomodels, University of Veterinary Medicine, Vienna, Austria.
Katrin MeisslAnimal Breeding and Genetics, Department of Biological Sciences and Pathobiology, University of Veterinary Medicine Vienna, Vienna, Austria.
Lena AmenitschAnimal Breeding and Genetics, Department of Biological Sciences and Pathobiology, University of Veterinary Medicine Vienna, Vienna, Austria.
Therese LedererAnimal Breeding and Genetics, Department of Biological Sciences and Pathobiology, University of Veterinary Medicine Vienna, Vienna, Austria.
Elena PohlPhysiology and Biophysics, Department of Biological Sciences and Pathobiology, University of Veterinary Medicine Vienna, Vienna, Austria.
Dagmar GotthardtDivision Pharmacology, Karl Landsteiner University of Health Sciences, Krems an Der Donau, Austria.
Christoph BockCemm Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Thomas DeckerMax Perutz Labs, Vienna Biocenter Campus (VBC), Vienna, Austria.
Birgit StroblAnimal Breeding and Genetics, Department of Biological Sciences and Pathobiology, University of Veterinary Medicine Vienna, Vienna, Austria.
Mathias MüllerAnimal Breeding and Genetics, Department of Biological Sciences and Pathobiology, University of Veterinary Medicine Vienna, Vienna, Austria. mathias.mueller@vetmeduni.ac.at.ORCID http://orcid.org/0000-0002-7879-3552

Funding

Austrian Science Fund SFB F6101Austrian Science Fund SFB F6102Austrian Science Fund SFB F6103Austrian Science Fund SFB F6106
6 · The paper itself

Abstract

Tyrosine kinase 2 (TYK2) deficiency and loss or inhibition of kinase activity in men and mice leads to similar immune compromised phenotypes, predominantly through impairment of interferon (IFN) and interleukin 12 family responses. Here we relate the transcriptome changes to phenotypical changes observed in TYK2-deficient (Tyk2

Indexed as

TYK2 KinaseAnimalsCD8-Positive T-LymphocytesKiller Cells, NaturalMacrophagesMiceMice, Inbred C57BLMice, KnockoutSignal TransductionSpleenTranscriptomeTYK2 KinaseTyk2 protein, mouseCD8+ T cellsInterferonJAK-STATMacrophagesNK cellsSplenic immune cellsTonic signalingTumor-infiltrating cells

Identifiers

PMID40025196
PMCPMC11872851

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.