Evidence map›Paper›PMID 40025188›Full record

ArticleScientific reports2025

A covalent chemical probe for Chikungunya nsP2 cysteine protease with antialphaviral activity and proteome-wide selectivity.

Anirban Ghoshal, Edwin G Tse, Mohammad Anwar Hossain, Kesatebrhan Haile Asressu, Eric M Merten, John D Sears, Stefanie Howell, Sumera Perveen, Jane Burdick, Noah L Morales and 17 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Journal of medicinal chemistry · 2025
    Article
  7. Article
  8. Species Dependent Metabolism of a Covalent nsP2 Protease Inhibitor withbioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

27 authors.

Anirban GhoshalStructural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Edwin G TseStructural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Mohammad Anwar HossainStructural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Kesatebrhan Haile AsressuStructural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Eric M MertenREADDI Avidd Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
John D SearsREADDI Avidd Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Stefanie HowellStructural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Sumera PerveenREADDI Avidd Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Jane BurdickREADDI Avidd Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Noah L MoralesREADDI Avidd Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Sabian A MartinezREADDI Avidd Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Isabella LawREADDI Avidd Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Bennett J DavenportREADDI Avidd Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Thomas E MorrisonREADDI Avidd Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Zachary J StreblowREADDI Avidd Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Daniel N StreblowREADDI Avidd Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Angie L MordantUNC Metabolomics and Proteomics Core, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Thomas S WebbUNC Metabolomics and Proteomics Core, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Aurora CabreraUNC Metabolomics and Proteomics Core, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Laura E HerringUNC Metabolomics and Proteomics Core, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Cheryl H ArrowsmithREADDI Avidd Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Kenneth H PearceREADDI Avidd Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Nathaniel J MoormanREADDI Avidd Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Mark T HeiseREADDI Avidd Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Rafael M CouñagoStructural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Peter J BrownStructural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Timothy M WillsonStructural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. tim.willson@unc.edu.

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5M
Research Project 1: Coronavirus antiviral lead development and combination testingU19AI171292 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BARIC, RALPH S, WILLSON, TIMOTHY M · 2022 to 2022
$65.5M
NCI NIH HHS P30 CA016086NIAID NIH HHS U19 AI171292NIH HHS 1U19AI171292-01NIH HHS P30CA016086-34
6 · The paper itself

Abstract

Chikungunya is a mosquito-borne viral disease that causes fever and severe joint pain for which there is no direct acting drug treatments. Vinyl sulfone SGC-NSP2PRO-1 (3) was identified as a potent inhibitor of the nsP2 cysteine protease (nsP2pro) that reduced viral titer against infectious isolates of Chikungunya and other alphaviruses. The covalent warhead in 3 captured the active site C478 and inactivated nsP2pro with a k

Indexed as

Antiviral AgentsChikungunya virusCysteine ProteasesCysteine Proteinase InhibitorsMolecular ProbesProteomeAnimalsChikungunya FeverCysteine EndopeptidasesHumansSulfonesAntiviral AgentsCysteine EndopeptidasesCysteine ProteasesCysteine Proteinase Inhibitorsdivinyl sulfoneMolecular ProbesnsP2 proteinaseProteomeSulfonesAlphavirusAntiviralChemical probeCovalent inhibitorCysteine protease

Identifiers

PMID40025188
PMCPMC11873239

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.